| 宫调音乐对结直肠癌术后化疗患者生存质量及细胞免疫的影响 |
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| 引用本文： | 赖优莹,邓皖利,马新文,付晓伶,杨柳,冯煜,张怡,刘慧,李琦.宫调音乐对结直肠癌术后化疗患者生存质量及细胞免疫的影响[J].上海中医药大学学报,2018,32(2):18-22. |
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| 作者姓名： | 赖优莹 邓皖利 马新文 付晓伶 杨柳 冯煜 张怡 刘慧 李琦 |
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| 作者单位： | 上海中医药大学附属曙光医院肿瘤科; |
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| 基金项目： | 国家自然科学基金青年基金资助项目(81403360)；上海市教委青年教师培养计划资助项目(ZZszy13016)；上海市卫计委青年医师培养计划资助项目 |
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| 摘 要： | 目的:探讨宫调音乐疗法对结直肠癌术后化疗患者生存质量及细胞免疫的影响。方法:选取结直肠癌术后脾气亏虚证化疗患者82例,随机分为化疗组和化疗加音乐组(简称"音乐组"),每组各41例。所有患者均给予FOLFOX6或Cape OX方案化疗,音乐组在化疗同时给予宫调音乐疗法,两组治疗周期均为4个化疗周期。比较两组患者脾气亏虚证的中医证候评分,采用欧洲癌症研究与治疗组织的生命质量核心量表(EORTC QLQ-C30V3.0)对患者进行生存质量评价,检测患者外周血中CD2~+、CD3~+、CD4~+T细胞比例。结果:治疗后,两组患者的中医证候总积分均明显升高(P0.05),其中音乐组患者的证候总积分较化疗组明显降低(P0.05)。治疗后,两组患者的EORTC QLQ-C30各项功能领域评分和总健康状况评分均明显下降(P0.05),而音乐组患者的躯体功能、角色功能、情绪功能、总体健康状况评分较化疗组明显升高(P0.05);两组患者的各项症状领域(包括疲倦、恶心呕吐、失眠、腹泻、经济困难)评分均明显升高(P0.05),化疗组患者的便秘评分亦显著升高(P0.05),而音乐组患者的疲倦、恶心呕吐、失眠、便秘、腹泻评分较化疗组明显降低(P0.05)。治疗后,化疗组患者的CD4~+比率较治疗前降低(P0.05),音乐组患者的CD2~+、CD3~+、CD4~+T细胞比率较治疗前升高(P0.05);且音乐组患者的CD2~+、CD3~+、CD4~+T细胞比率较化疗组亦明显升高(P0.05)。结论:宫调音乐能提高结直肠癌术后化疗患者的生存质量,改善患者的中医证候,其机制可能与促进外周血中CD2~+、CD3~+、CD4~+表达,调控机体的免疫功能相关。
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| 关 键 词： | 结直肠癌 术后 化疗 音乐疗法 宫调 生存质量 细胞免疫 |
Effects of Gong-tune music on quality of life and cellular immunity in postoperative chemotherapy patients with colorectal carcinoma |
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| LAI Youying,DENG Wanli,MA Xinwen,FU Xiaoling,YANG Liu,FENG Yu,ZHANG Yi,LIU Hui and LI Qi.Effects of Gong-tune music on quality of life and cellular immunity in postoperative chemotherapy patients with colorectal carcinoma[J].Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai,2018,32(2):18-22. |
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| Authors: | LAI Youying DENG Wanli MA Xinwen FU Xiaoling YANG Liu FENG Yu ZHANG Yi LIU Hui and LI Qi |
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| Institution: | Department of Oncology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203,China,Department of Oncology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203,China,Department of Oncology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203,China,Department of Oncology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203,China,Department of Oncology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203,China,Department of Oncology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203,China,Department of Oncology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203,China,Department of Oncology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203,China and Department of Oncology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203,China |
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| Abstract: | |
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| Keywords: | colorectal carcinoma postoperative chemotherapy music therapy Gong-tune quality of life cellular immunity |
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