| 舒筋合剂联合西药治疗肝肾阴虚型类风湿关节炎66例 |
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| 引用本文： | 姜婷,程鹏,沈杰,朱琦,岳涛,汪荣盛,陈继红,张湛明,唐小蓉,沈逸,丁琴,白凤敏,何东仪. 舒筋合剂联合西药治疗肝肾阴虚型类风湿关节炎66例[J]. 上海中医药大学学报, 2018, 32(1): 30-34 |
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| 作者姓名： | 姜婷 程鹏 沈杰 朱琦 岳涛 汪荣盛 陈继红 张湛明 唐小蓉 沈逸 丁琴 白凤敏 何东仪 |
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| 作者单位： | 扬州大学医学院;上海市光华中西医结合医院; |
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| 基金项目： | 上海市进一步加快中医药事业发展三年行动计划中医临床基地建设项目(ZY3-LCPT-1)；上海市中医药事业发展三年行动计划“杏林新星计划”项目(ZY3-RCPY-2-2045) |
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| 摘 要： | 目的:观察舒筋合剂联合西药治疗肝肾阴虚型类风湿关节炎(RA)的临床疗效及安全性。方法:将符合观察标准的132例患者随机分为治疗组和对照组,每组各66例。两组均予甲氨喋呤与来氟米特,治疗组同时加舒筋合剂,疗程均为12周。观察患者症状体征、中医证候、血沉(ESR)、C反应蛋白(CRP)以及28个关节活动评分(DAS 28)反应情况,并评价其安全性。结果:(1)治疗组与对照组的总有效率分别为60.34%、45.00%,差异无统计学意义(P0.05);中医证候疗效分别为86.21%和70.00%,差异有统计学意义(P0.05)。(2)两组晨僵持续时间、肿胀关节数、压痛关节数、整体状况评估、ESR、CRP等指标的改善情况相当(P0.05),但治疗组的DAS 28评分的改善情况却优于对照组(P0.05);治疗组的中医证候积分在治疗8周后、12周后的改善情况均优于对照组(P0.05),其中医次症(口渴、乏力、大便干)的改善情况亦优于对照组(P0.05或P0.01)。(3)两组不良反应发生率分别为9.1%和7.6%,差异无统计学意义(P0.05)。结论:舒筋合剂联合西药治疗肝肾阴虚型RA的短期疗效虽不优于单用西药,但能有效改善部分肝肾阴虚证候、降低疾病活动度,且安全性较好。
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| 关 键 词： | 类风湿关节炎 舒筋合剂 肝肾阴虚 中西医结合疗法 |
Shujin Mixture combined with western medicine in the treatment of rheumatoid arthritis with syndrome of yin deficiency of liver and kidney:66 cases report |
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| JIANG Ting,CHENG Peng,SHEN Jie,ZHU Qi,YUE Tao,WANG Rongsheng,CHEN Jihong,ZHANG Zhanming,TANG Xiaorong,SHEN Yi,DING Qin,BAI Fengmin and HE Dongyi. Shujin Mixture combined with western medicine in the treatment of rheumatoid arthritis with syndrome of yin deficiency of liver and kidney:66 cases report[J]. Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai, 2018, 32(1): 30-34 |
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| Authors: | JIANG Ting CHENG Peng SHEN Jie ZHU Qi YUE Tao WANG Rongsheng CHEN Jihong ZHANG Zhanming TANG Xiaorong SHEN Yi DING Qin BAI Fengmin HE Dongyi |
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| Affiliation: | Yangzhou University School of Medicine,Yangzhou 225000,China;Shanghai Guanghua Hospital of Integrated Chinese and Western Medicine,Shanghai 200052,China,Shanghai Guanghua Hospital of Integrated Chinese and Western Medicine,Shanghai 200052,China,Shanghai Guanghua Hospital of Integrated Chinese and Western Medicine,Shanghai 200052,China,Shanghai Guanghua Hospital of Integrated Chinese and Western Medicine,Shanghai 200052,China,Shanghai Guanghua Hospital of Integrated Chinese and Western Medicine,Shanghai 200052,China,Shanghai Guanghua Hospital of Integrated Chinese and Western Medicine,Shanghai 200052,China,Shanghai Guanghua Hospital of Integrated Chinese and Western Medicine,Shanghai 200052,China,Shanghai Guanghua Hospital of Integrated Chinese and Western Medicine,Shanghai 200052,China,Shanghai Guanghua Hospital of Integrated Chinese and Western Medicine,Shanghai 200052,China,Shanghai Guanghua Hospital of Integrated Chinese and Western Medicine,Shanghai 200052,China,Shanghai Guanghua Hospital of Integrated Chinese and Western Medicine,Shanghai 200052,China,Shanghai Guanghua Hospital of Integrated Chinese and Western Medicine,Shanghai 200052,China and Shanghai Guanghua Hospital of Integrated Chinese and Western Medicine,Shanghai 200052,China |
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