| 蝎蜈胶囊联合川芎平喘合剂对痰瘀互结型发作期支气管哮喘肺功能及细胞因子的影响 |
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| 引用本文： | 陆城华,孟凯,徐倍琪,徐向前,马子风,张惠勇. 蝎蜈胶囊联合川芎平喘合剂对痰瘀互结型发作期支气管哮喘肺功能及细胞因子的影响[J]. 上海中医药杂志, 2018, 52(4): 62-65 |
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| 作者姓名： | 陆城华 孟凯 徐倍琪 徐向前 马子风 张惠勇 |
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| 作者单位： | 上海中医药大学附属龙华医院肺病科;上海市徐汇区中心医院中医科; |
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| 基金项目： | 上海市卫计委科研计划项目(20154Y0022)；国家自然科学基金项目(81503508) |
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| 摘 要： | 目的观察蝎蜈胶囊联合川芎平喘合剂治疗痰瘀互结型支气管哮喘发作期的临床疗效。方法将104例痰瘀互结型支气管哮喘发作期患者随机分为治疗组和对照组,每组52例。治疗组予蝎蜈胶囊联合川芎平喘合剂治疗,对照组予复方甲氧那明胶囊口服及布地奈德粉吸入剂。两组疗程均为7天,观察临床疗效,比较中医证候积分、肺功能指标及相关细胞因子的变化情况。结果 (1)治疗组、对照组临床总有效率分别为86.5%、75.0%;组间临床疗效比较,治疗组明显优于对照组(P0.05)。(2)治疗前后组内比较,两组中医证候积分差异均有统计学意义(P0.05);组间治疗前后差值比较,差异有统计学意义,治疗组中医证候积分降低幅度明显大于对照组(P0.05)。(3)治疗前后组内比较,两组用力肺活量(FVC)、第1秒用力呼气量(FEV_1)、最大呼气流速(PEF)水平差异均有统计学意义(P0.05);组间治疗后比较,FEV_1、PEF水平差异有统计学意义,治疗组改善明显优于对照组(P0.05),而FVC差异无统计学意义(P0.05)。(4)治疗前后组内比较,两组血清白细胞介素-4(IL-4)、γ干扰素(IFN-γ)水平差异均有统计学意义(P0.05);组间治疗后比较,IL-4、IFN-γ水平差异无统计学意义(P0.05)。结论蝎蜈胶囊联合川芎平喘合剂治疗痰瘀互结型支气管哮喘发作期的疗效满意,可明显缓解患者临床症状及肺通气功能,其机制可能与纠正Th1/Th2细胞功能失衡有关。
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| 关 键 词： | 支气管哮喘 哮病 痰瘀互结 川芎平喘合剂 蝎蜈胶囊 名医验方 |
| 收稿时间： | 2017-11-26 |
Effects of Xiewu Capsule combined with Chuanxiong Pingchuan Mixture on pulmonary function and cytokines in bronchial asthma of attack stage with syndrome of intermingled phlegm and blood stasis |
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| LU Chenghu,MENG Kai,XU Beiqi,XU Xiangqian,MA Zifeng and ZHANG Huiyong. Effects of Xiewu Capsule combined with Chuanxiong Pingchuan Mixture on pulmonary function and cytokines in bronchial asthma of attack stage with syndrome of intermingled phlegm and blood stasis[J]. Shanghai Journal of Traditional Chinese Medicine, 2018, 52(4): 62-65 |
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| Authors: | LU Chenghu MENG Kai XU Beiqi XU Xiangqian MA Zifeng ZHANG Huiyong |
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| Affiliation: | Department of Pulmonary Diseases,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China,Department of Traditional Chinese Medicine,Central Hospital of Xuhui District,Shanghai 200031,China,Department of Pulmonary Diseases,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China,Department of Pulmonary Diseases,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China,Department of Pulmonary Diseases,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China and Department of Pulmonary Diseases,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China |
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| Abstract: | |
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| Keywords: | bronchial asthma asthma intermingled phlegm and blood stasis Chuanxiong Pingchuan Mixture Xiewu Capsule empirical formula of famous doctor |
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