| 健脾解毒方防治大肠癌术后化疗相关周围神经病变的临床研究 |
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| 引用本文： | 范越,厉天瑜,张雯,程悦蕾,张怡,李琦,朱惠蓉. 健脾解毒方防治大肠癌术后化疗相关周围神经病变的临床研究[J]. 上海中医药杂志, 2018, 52(10): 49-53 |
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| 作者姓名： | 范越 厉天瑜 张雯 程悦蕾 张怡 李琦 朱惠蓉 |
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| 作者单位： | 上海中医药大学附属曙光医院肿瘤科;复旦大学附属中山医院中西医结合科 |
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| 基金项目： | 上海市科委中医引导专项(16401930700) |
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| 摘 要： | 目的观察健脾解毒方防治大肠癌术后化疗相关周围神经病变的临床疗效。方法将64例大肠癌术后患者随机分为对照组和治疗组,每组32例。对照组予XELOX化疗方案,治疗组在化疗基础上加服健脾解毒方。两组计划疗程均为8个化疗周期,观察化疗完成周期、出现首次慢性累积性化疗相关周围神经病变(CIPN)症状周期、奥沙利铂计划治疗剂量的完成率以及3~4度骨髓抑制发生次数,比较美国国立癌症研究所-药物常见毒性分级标准量表(NCI-CTCAE)分级、癌症治疗功能评价系统/妇科肿瘤组-神经毒性评价工具量表(FACT/GOG-Ntx)评分、肿瘤患者神经毒性问卷(PNQ)分级及血清IL-1β水平的变化情况。结果 (1)最终完成试验者60例,治疗组31例,对照组29例。(2)两组在化疗完成周期方面比较,差异无统计学意义(P0.05)。两组奥沙利铂计划治疗剂量完成率比较,差异有统计学意义,治疗组明显高于对照组(P0.05)。两组出现首次累积性CIPN症状周期比较,差异有统计学意义,治疗组明显晚于对照组(P0.05)。两组3~4度骨髓抑制发生次数比较,差异无统计学意义(P0.05)。(3)化疗中与化疗后组内比较,两组NCI-CTCAE分级、FACT/GOG-Ntx评分差异均有统计学意义(P0.05)。组间化疗中比较,NCI-CTCAE分级、FACT/GOG-Ntx评分差异有统计学意义,治疗组明显低于对照组(P0.05);组间化疗后比较,NCI-CTCAE分级、FACT/GOG-Ntx评分差异有统计学意义,治疗组明显低于对照组(P0.05)。(4)化疗中与化疗后组内比较,两组PNQ1分级差异均有统计学意义(P0.05),而两组PNQ2分级差异均无统计学意义(P0.05)。组间化疗中比较,PNQ1分级、PNQ2分级差异有统计学意义,治疗组分级明显低于对照组(P0.05);组间化疗后比较,PNQ1分级、PNQ2分级差异有统计学意义,治疗组明显低于对照组(P0.05)。(5)治疗前与化疗半程、化疗后组内分别比较,两组IL-1β水平差异均有统计学意义(P0.05);治疗组IL-1β水平明显降低,而对照组IL-1β水平明显升高(P0.05)。组间化疗半程比较,IL-1β水平差异有统计学意义,治疗组明显低于对照组(P0.05);组间化疗后比较,IL-1β水平差异有统计学意义,治疗组明显低于对照组(P0.05)。结论健脾解毒方可明显减轻大肠癌术后化疗的致周围神经病变毒性,提高患者接受化疗的依从性和耐受性,使化疗获益最大化,进而提高患者的生存质量。
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| 关 键 词： | 结直肠癌 术后化疗 化疗相关周围神经病变 健脾解毒方 减毒增效 |
| 收稿时间： | 2018-05-18 |
Clinical study on Jianpi Jiedu Decoction in preventing and treating chemotherapy-related peripheral neuropathy in postoperative patients with colorectal cancer |
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| FAN Yue,LI Tianyu,ZHANG Wen,CHENG Yuelei,ZHANG Yi,LI Qi and ZHU Huirong. Clinical study on Jianpi Jiedu Decoction in preventing and treating chemotherapy-related peripheral neuropathy in postoperative patients with colorectal cancer[J]. Shanghai Journal of Traditional Chinese Medicine, 2018, 52(10): 49-53 |
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| Authors: | FAN Yue LI Tianyu ZHANG Wen CHENG Yuelei ZHANG Yi LI Qi ZHU Huirong |
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| Affiliation: | Department of Oncology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;Department of Integrated Chinese and Western Medicine, Zhongshan Hospital Affiliated to Fudan University, Shanghai 200032, China,Department of Integrated Chinese and Western Medicine, Zhongshan Hospital Affiliated to Fudan University, Shanghai 200032, China,Department of Integrated Chinese and Western Medicine, Zhongshan Hospital Affiliated to Fudan University, Shanghai 200032, China,Department of Oncology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China,Department of Oncology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China,Department of Oncology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China and Department of Oncology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China |
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| Abstract: | |
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| Keywords: | colorectal cancer postoperative chemotherapy chemotherapy-related peripheral neuropathy Jianpi Jiedu Decoction reducing toxicity and enhancing efficac |
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