自拟养元汤改善I型心肾综合征心肾功能的临床效果及可能的作用机制

目的:探讨自拟养元汤改善Ⅰ型心肾综合征心肾功能的临床效果及可能的作用机制。方法:选取2016年5月至2017年5月廊坊市中医医院收治的I型心肾综合征患者136例,按照随机数字表法随机分为对照组与观察组,每组68例。对照组患者给予常规治疗,观察组患者则加用自拟养元汤内服,比较2组的临床效果,观察心肾功能相关指标变化,监测治疗前后血清超氧化物歧化酶(SOD)、乳酸脱氢酶(LDH)、心脏脂肪酸结合蛋白(H-FABP)水平。结果:观察组有效率为92.6%,显著高于对照组的77.9%(P0.05);观察组患者治疗后心肾功能改善改善优于对照组,其LVDD、BUN、SCr水平较对照组显著降低,LVEF则较对照组显著升高(P0.05);治疗后观察组患者血清SOD水平显著高于对照组,而LDH、H-FABP水平则显著低于对照组(P0.05)。结论:自拟养元汤改善Ⅰ型心肾综合征心肾功能的临床效果肯定,机制可能在于调控血清中SOD、LDH、H-FABP水平以减轻肾功能损害及心肌损伤。

Clinical Effects and Possible Mechanism of Self-made Yangyuan Decoction in the Improvement of Heart-kidney Function of Type I Cardiorenal Syndrome

To explore the clinical effects and possible mechanism Self-made Yangyuan Decoction in the improvement of heart-kidney function of Type I Cardiorenal Syndrome.Methods:A total of 136 cases of patients with Type I Cardiorenal Syndrome were admitted and treated in Langfang Hospital of Traditional Chinese Medicine from May 2016 to May 2017,and they were randomly divided into the control group and the observation group,with 68 cases in each group.The patients in the control group were given conventional treatment; while patients in the observation group were given Self-made Yangyuan decoction.Changes of related indexes of heart-kidney function were observed.The levels of SOD,LDH and H-FABP were tested before and after treatment.Results:The efficiency of the patients in observation group was 92.6%,which was higher than that of the control group (77.9%) (P<0.05); The improvement of heart-kidney function of patients in observation group were better than those in the control group,and the levels of LVDD,BUN and SCr were lower than those of the control group,while the level of LVEF for the patients in observation group was significantly higher than that of the control group (P<0.05); the SOD levels were higher than those of the control group,while the levels of LDH and H-FABP for the patients in observation group were lower than those of the control group (P<0.05).Conclusion:The clinical effects of self-made Yangyuan Decoction were good in improving the patients'' heart kidney function,and the mechanism may be associated with regulation of the levels of SOD,LDH and H-FABP,which can reduce renal impairment and myocardial injury.