| 乳痈方调节乳腺菌群治疗哺乳期乳腺炎的临床研究 |
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| 引用本文： | 陶颖娜,万华,仲姗姗,冯佳梅,高晴倩.乳痈方调节乳腺菌群治疗哺乳期乳腺炎的临床研究[J].上海中医药杂志,2018,52(5):46-50. |
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| 作者姓名： | 陶颖娜 万华 仲姗姗 冯佳梅 高晴倩 |
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| 作者单位： | 上海中医药大学附属曙光医院乳腺科;上海市普陀区妇婴保健院乳腺科;上海市黄浦区中心医院中医外科 |
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| 基金项目： | 上海市卫计委中医药科研专项(2016LQ020)；上海市科委科研计划项目(14401971000)；上海市卫计委中医薄弱领域专科建设项目(2017-2019) |
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| 摘 要： | 目的观察乳痈方治疗哺乳期乳腺炎的临床疗效及其可能的机制。方法对52例哺乳期乳腺炎患者予以中药乳痈方治疗,疗程为1周(7 d),并采用自身前后对照及自身双侧乳房对照的研究方法。观察比较治疗前后临床症状体征(乳房肿块、乳房胀痛、乳汁欠畅、乳腺局部皮色灼热、恶寒发热)评分的变化情况;并进行双侧乳房乳汁中各类致病菌、益生菌的定性、定量测定。结果(1)治疗前后比较,患者乳房肿块明显缩小(P0.05),乳房胀痛明显缓解(P0.05),乳汁欠畅明显改善(P0.05),乳房局部皮色灼热明显缓解(P0.05),恶寒发热明显好转(P0.05)。(2)治疗前后比较,患侧乳汁中的致病菌明显减少(P0.05)。(3)治疗前,患侧乳汁中与健侧乳汁中的葡萄球菌、链球菌、双歧杆菌、乳酸杆菌定量Ct值比较,差异无统计学意义(P0.05)。(4)治疗前后同侧比较,患者两侧葡萄球菌及双歧杆菌、乳酸杆菌定量Ct值差异均有统计学意义(P0.05);两侧治疗前后各类菌群Ct值差值比较,葡萄球菌Ct值差值患侧增多更明显,即葡萄球菌数量患侧减少更明显(P0.05),双歧杆菌Ct值差值患侧减少更明显,即双歧杆菌数量患侧增多更明显(P0.05),乳酸杆菌Ct值差值差异无统计学意义(P0.05)。(5)链球菌感染患者本研究仅发现1例,其患侧乳汁中的链球菌数量存在减少趋势,双歧杆菌和乳酸杆菌的数量存在增多趋势。(6)治疗前后同侧比较,患者两侧双歧杆菌定量Ct值差异均有统计学意义(P0.05),两侧乳酸杆菌定量Ct值差异无统计学意义(P0.05);两侧治疗前后双歧杆菌Ct值差值比较,患侧减少更明显,即细菌数量患侧增多更明显(P0.05),乳酸杆菌Ct值差值差异无统计学意义(P0.05)。结论乳痈方治疗哺乳期乳腺炎的疗效满意,可明显缓解患者的临床症状体征,其机制可能是通过调节乳腺菌群(减少致病菌、增加益生菌)而起效。
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| 关 键 词： | 哺乳期乳腺炎 乳痈方 肝胃郁热 乳腺菌群调节 葡萄球菌 双歧杆菌 |
| 收稿时间： | 2017/12/18 0:00:00 |
Clinical study on Ruyong Formula in treating lactational mastitis by regulating mammary gland flora |
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| TAO Yingn,WAN Hu,ZHONG Shanshan,FENG Jiamei and GAO Qingqian.Clinical study on Ruyong Formula in treating lactational mastitis by regulating mammary gland flora[J].Shanghai Journal of Traditional Chinese Medicine,2018,52(5):46-50. |
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| Authors: | TAO Yingn WAN Hu ZHONG Shanshan FENG Jiamei and GAO Qingqian |
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| Institution: | Department of Breast,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200021,China;Department of Breast,Shanghai Maternity and Infant Health Care Hospital of Putuo District,Shanghai 200062,China,Department of Breast,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200021,China,Department of Chinese Medical Surgery,Shanghai Central Hospital of Huangpu District, Shanghai 200002,China,Department of Breast,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200021,China and Department of Breast,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200021,China |
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| Abstract: | |
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| Keywords: | lactational mastitis Ruyong Formula stagnated heat in liver and stomach regulation of mammary gland flora Staphylococcus Bifidobacteria |
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