芙蓉软膏对大鼠皮肤疮疡影响的药效学研究

目的研究芙蓉软膏对大鼠皮肤疮疡的药效学,为临床安全合理使用提供实验依据。方法将40只雄性SD大鼠分为空白组、模型组、百多邦(莫匹罗星软膏)组、芙蓉软膏组,每组10只。除空白组外,其余大鼠通过对皮肤划损致感染的方法,建立大鼠皮肤疮疡模型。各组进行相应干预。观察芙蓉软膏对大鼠体质量、进食情况、毛色、活动情况、疮疡处组织、伤口愈合时间、体表温度及血常规等各项相关指标的影响。结果给药第4 d,与空白组比较,模型组大鼠WBC明显升高(P0.01),提示造模成功。与模型组比较,百多邦组和芙蓉软膏组大鼠WBC明显降低(P0.05);给药第7 d,与空白组比较,模型组MCH、MCHC明显升高(P0.01),与模型组比较,百多邦组WBC、MCH明显降低(P0.05),芙蓉软膏组WBC、MCH明显降低(P0.05)。给药第7 d,与模型组比较,百多邦组、芙蓉软膏组愈合动物数均明显增加(P0.05);两组给药3~7 d大鼠疮疡分值均明显降低(P0.05,P0.01)。结论芙蓉软膏具有促进创面愈合的作用。

Pharmacodynamics study of Furong Ointment on skin ulcer in rats

  Objective:To evaluate the pharmacodynamics of Furong Ointment on skin ulcer in rats, and provide theoretical basis for its safe and rational application in clinic. Methods40 male SD rats were divided into the blank group, model group, Bactroban (Mupirocin Ointment) group and Furong Ointment group, 10 rats in each group. Except the blank group, the rat model of skin ulcer was established in other groups by infection due to skin scratching. Each group was treated with the corresponding intervention. The effects of Furong Ointment on the related indicators such as body weight, feeding, hair color, activity, ulcer tissue, wound healing time, surface temperature and routine blood indexes were observed.  Results:On the fourth day of administration, compared with the blank group, the WBC in the model group was increased significantly (P<0.01), which suggested that the model was successful. Compared with the model group, the WBC in the Bactroban group and the Furong Ointment group was decreased significantly (P<0.05). On the seventh day of administration, compared with the blank group, the MCH and MCHC in the model group were significantly increased (P<0.01). Compared with the model group, the WBC and MCH in the Bactroban group were significantly decreased (P<0.05), and the WBC and MCH in the Furong Ointment group were significantly decreased (P<0.05). On the seventh day of administration, compared with the model group, the number of healed animals was increased significantly in both Bactroban group and Furong Ointment group (P<0.05). After treatment for 3 to 7 days, the score of ulcer was decreased significantly in both groups (P<0.05, P<0.01).  Conclusion:Furong Ointment can promote the wound healing.