扶正防癌方联合化疗对脾肾两虚型晚期胃癌的临床疗效

目的:探讨采用具有补益脾肾作用的扶正防癌方联合替吉奥胶囊治疗脾肾两虚型晚期胃癌患者的临床疗效。方法:选取2013年7月至月2016年1月北京中医医院将符合入选标准的胃癌晚期患者80例,按随机数字法分为2组,观察组和对照组各40例。比较2组治疗前后实体瘤近期疗效、体重及Karnofsky评分、生命质量QOL-C30评分、中医证候评分、药物不良反应。结果:观察组体重及Karnofsky评分、中医证候评分、生命质量QOL-C30评分较对照组显著升高(P0.05);2组实体瘤近期疗效比较,差异无统计学意义(P0.05);观察组不良反应发生率要少于对照组,2组比较,差异无统计学意义(P0.05)。结论:扶正防癌方联合化疗对晚期胃癌实体瘤疗效上虽无明显优势,但有助于改善患者临床症状和提高生命质量,并在一定程度上抑制化疗药物不良反应,是晚期胃癌患者可选择的有效的临床治疗方法之一。

Observation on Clinical Efficacy of Fuzheng Anti-cancer Prescription Combined with Chemotherapy in Deficiency on Spleen and Kidney in Patients with Advanced Gastric Cancer

To explore the clinical efficacy of the effect of the method of invigorating spleen and kidney combined with chemotherapy for advanced gastric cancer patients.Methods:A total of 80 patients with advanced gastric cancer who met the inclusion criteria in Beijing Hospital of Traditional Chinese Medicine from July 2013 to January 2016 were randomly divided into treatment group and control group, with 40 cases in each group.The short-term curative effect, body mass and Karnofsky score, quality of life, QOL-C30 score and TCM syndrome score were compared between the two groups before and after treatment.Results:The body mass and Karnofsky score, TCM syndrome score and quality of life QOL-C30 score were significantly higher in the treatment group than in the control group (P<0.05), while the short-term curative effect of the solid tumors was not significantly different between the two groups (P>0.05).Conclusion:The traditional Chinese medicine of Fuzheng Fangai decoction combined with chemotherapy for advanced gastric cancer tumor entity does not have obvious advantages, but it helps to improve the clinical symptoms and improve the quality of life, which is one of the effective clinical treatment for patients with advanced gastric cancer that can be selected.