| 精子染色质结构异常对体外受精-胚胎移植结局的影响 |
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| 引用本文： | 谷龙杰,陈振文,卢文红,许剑锋,李梅,陈子江. 精子染色质结构异常对体外受精-胚胎移植结局的影响[J]. 中华医学遗传学杂志, 2011, 28(1): 156-159. DOI: 10.3760/cma.j.issn.1003-9406.2011.02.008 |
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| 作者姓名： | 谷龙杰 陈振文 卢文红 许剑锋 李梅 陈子江 |
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| 作者单位： | 华中科技大学同济医学院附属同济医院生殖医学中心,武汉,430030;国家人口计生委科学技术研究所男性临床研究室;山东大学附属省立医院生殖医学中心; |
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| 摘 要： | Objective To explore the effects of sperm chromatin structure abnormalities on the outcome of in vitro fertilization and embryo transfer (IVF-ET). Methods Sperm DNA fragmentation and chromatin packaging defects were assessed in 136 couples undergoing IVF-ET because of infertility. The relationship between sperm DNA fragmentation, chromatin packaging defects and fertilization rate and clinical pregnancy was evaluated. Results Both sperm DNA fragmentation and chromatin packaging defect had a negative correlation with fertilization rate (r= -0. 198, P＜0. 05, and r= -0. 389, P＜0. 01,respectively). Both parameters were higher in couples who failed to achieve pregnancy than those who achieved clinical pregnancy (10. 74% vs. 5. 40%, P＜0. 01 and 23. 58% vs. 11. 83%, P＜0. 01,respectively). Conclusion Abnormality of sperm chromatin structure is one of the reasons for IVF-ET failure. Examination of sperm chromatin structure is helpful in predicting he risk of IVF-ET failure and optimizing treatment of infertility.
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| 关 键 词： | 不育症 体外受精 胚胎移植 精子 染色质 |
Effects of abnormal structure of sperm chromatin on the outcome of in vitro fertilization and embryo transfer |
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| GU Long-jie,CHEN Zhen-wen,LU Wen-hong,XU Jian-feng,LI Mei,CHEN Zi-jiang. Effects of abnormal structure of sperm chromatin on the outcome of in vitro fertilization and embryo transfer[J]. Chinese journal of medical genetics, 2011, 28(1): 156-159. DOI: 10.3760/cma.j.issn.1003-9406.2011.02.008 |
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| Authors: | GU Long-jie CHEN Zhen-wen LU Wen-hong XU Jian-feng LI Mei CHEN Zi-jiang |
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| Abstract: | |
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| Keywords: | infertilityin vitro fertilizationembryo transferspermatozoachromatin |
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