| 孕期甲状腺功能与妊娠期胆汁淤积症关系的临床研究 |
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| 引用本文： | 周红,王秋伟,曹芳,黄瑞萍,朱自强,孙达成,虞斌.孕期甲状腺功能与妊娠期胆汁淤积症关系的临床研究[J].中华全科医师杂志,2011,10(1):417-419. |
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| 作者姓名： | 周红 王秋伟 曹芳 黄瑞萍 朱自强 孙达成 虞斌 |
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| 作者单位： | 江苏省常州市妇幼保健院生殖健康实验室,213003; |
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| 基金项目： | 江苏省常州市卫生局资助项目 |
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| 摘 要： | 采用电化学发光技术对166例妊娠期肝内胆汁淤积症(ICP)患者血清促甲状腺激素(TSH)、游离甲状腺素(FT4)、甲状腺过氧化物酶抗体(TPOAb)水平进行检测,并与正常妊娠妇女及参与筛查的妊娠妇女进行比较.结果 显示,与正常妊娠妇女比较,ICP孕妇血清TSH、TPOAb明显升高,FT4水平无明显变化,其TPOAb阳性率达22.9%(38/166).ICP孕妇易合并各种甲状腺疾病,总发生率35.5%(59/166),明显高于同期筛查妊娠妇女17.1%(143/837).妊娠期ICP妇女甲状腺功能存在异常,可能参与了ICP的发生及发展.
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| 关 键 词： | 胆汁淤积 甲状腺疾病 |
Correlation between internal thyroid function and intrahepatic cholestasis in pregnancy |
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| ZHOU Hong,WANG Qiu-wei,CAO Fang,HUANG Rui-ping,ZHU Zi-qiang,SUN Da-cheng,YU Bin.Correlation between internal thyroid function and intrahepatic cholestasis in pregnancy[J].Chinese JOurnal of General Practitioners,2011,10(1):417-419. |
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| Authors: | ZHOU Hong WANG Qiu-wei CAO Fang HUANG Rui-ping ZHU Zi-qiang SUN Da-cheng YU Bin |
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| Abstract: | A total of 166 women with intrahepatic cholestasis in pregnancy (ICP) participated in the study. Serum levels of thyroid stimulating hormone (TSH), free thyroxine 4 (FT4) and thyroid peroxidase antibody (TPOAb) were quantified for all of them with electrochemiluminescence (ECL) technique, and compared with those in normal pregnant women. Results showed that serum TSH and TPOAb 22. 9%(38/166)] increased significantly, but no significant change in serum level of FT4 was observed in women with ICP, as compared to those in normal pregnant women. Overall prevalence of thyroid diseases in ICP women was 35.5% (59/166), significantly higher than that in normal population screened for thyroid disease (17. 1%, 143/837) at the same time period. It suggests that thyroid dysfunction may be involved in pathogenesis of ICP. |
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| Keywords: | CholestasisThyroid disease |
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