| 2型糖尿病患者糖尿病视网膜病变不同时期外周血内皮祖细胞的数量变化 |
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| 引用本文： | 王凡,武志峰,管怀进,魏云玉,卢百阳,张洁.2型糖尿病患者糖尿病视网膜病变不同时期外周血内皮祖细胞的数量变化[J].中华眼底病杂志,2011,27(1):222-225. |
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| 作者姓名： | 王凡 武志峰 管怀进 魏云玉 卢百阳 张洁 |
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| 作者单位： | 南京医科大学附属无锡第二医院眼科,214000;南通大学附属医院眼科中心;南京医科大学附属无锡第二医院检验科,214000;连云港市第一人民医院眼科; |
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| 基金项目： | 江苏省重点学科南通医科大学南通大学附属医院眼科开放课题 |
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| 摘 要： | Objective To observe the amount of endothelial progenitor cells(EPCs)at different stages of diabetic retinopathy(DR)in patients with type 2 diabetes mellitus(DM).Methods Sixty patients with type 2 DM were divided into no DR(NDR)group,non-proliferative DR(NPDR)group and proliferative DR(PDR)group according to the examination of fundus and fundus fluorescein angiography,20patients in each group.Twenty healthy people were collected as the control group.6 ml blood samples were taken from all the subjects,and then the EPCs contents in peripheral blood were detected by flow cytometry.Results The EPCs contents in peripheral blood of the control,NDR,NPDR and PDR group were(0.0179±0.0047)% ,(0.0151±0.0086)% ,(0.0123±0.1137)% ,(0.0316±0.0294)% .The EPCs contents in peripheral blood of the PDR group was significantly higher than those in others(χ2=43.780,P＜0.05);the EPCs contents in peripheral blood of the NDR and NPDR group were slightly lower than that in the control group(χ2=5.244,P=0.73);the EPCs contents in peripheral blood of the NPDR group was lower than that in the NDR group(χ2=6.0 1 6,P=0.12).Conclusion The EPCs contents in peripheral blood decreases in NDR,NPDR patients,while significantly increases in PDR patients.
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| 关 键 词： | 糖尿病视网膜病变/病理生理学 内皮 血管 造血干细胞 糖尿病 2型/并发症 |
The amount of endothelial progenitor cells at different stages of diabetic retinopathy in patients with type 2 diabetes mellitus |
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| Abstract: | |
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| Keywords: | Diabetic retinopathy/pathophysiologyEndothelium vascularMyeloid progenitor cellsDiabetes mellitus type 2/complications |
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