| Mir-145在肝癌细胞及肝癌组织中的表达及其意义 |
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| 引用本文： | 严斌,李艳兵,吕兴,曾少波,江斌. Mir-145在肝癌细胞及肝癌组织中的表达及其意义[J]. 中华实验外科杂志, 2011, 28(1): 707-709. DOI: 10.3760/cma.j.issn.1001-9030.2011.05.022 |
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| 作者姓名： | 严斌 李艳兵 吕兴 曾少波 江斌 |
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| 作者单位： | 湖北医药学院附属太和医院肝胆外科,湖北十堰,442000; |
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| 摘 要： | Objective To explore the role of miR-145 in human hepatocellular carcinoma ( HCC). We investigate the expression of miR-145 in human embryonic hepatocytes ( L02 cells),hepatocellular carcinoma cell lines (MHCC97 ,SMMC7721) ,HCC tissues and normal liver. Methods We detected the expressions of miR-145 in human embryonic hepatocytes, hepatocellular carcinoma cell lines ( MHCC97,SMMC7721) ,HCC tissues,cancer organizations and normal liver by real-time PCR. Result The expression of miR-145 in hepatocellular carcinoma cell lines ( MHCC97,SMMC7721) is significantly lower than the human embryonic hepatocytes ( 0. 312 ± 0. 025,0. 396 ± 0. 076,0. 954 ± 0. 037, P ＜ 0. 05), and compared with the cancer organizations and normal liver,the expression of miR-145 in HCC tissues is significantly decreased (0. 162 ±0.002,0. 972 ±0.054,0.956 ±0. 018,P＜0. 05). Conclusion These results indicate that the miR-145 probably involved in HCC pathogenesis and was the indicator of diagnosis and prognosis of the HCC.
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| 关 键 词： | 肝细胞癌 实时定量PCR |
Expression of miR-145 in hepatocellular carcinoma and its significance |
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| YAN Bin,LI Yan-bing,LU Xing,ZENG Shao-bo,JIANG Bin. Expression of miR-145 in hepatocellular carcinoma and its significance[J]. Chinese Journal of Experimental Surgery, 2011, 28(1): 707-709. DOI: 10.3760/cma.j.issn.1001-9030.2011.05.022 |
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| Authors: | YAN Bin LI Yan-bing LU Xing ZENG Shao-bo JIANG Bin |
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| Abstract: | |
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| Keywords: | miR-145miR-145HCCReal-time PCR |
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