调节性T淋巴细胞与严重烧伤脓毒症

许多资料显示,大面积烧伤并发的脓毒症来势凶猛,病情进展迅速,患者病死率高,给临床救治工作带来极大困难.及时诊断、有效预防和治疗烧伤脓毒症,是提高严重烧伤救治成功率的关键.随着对感染病理生理过程认识的不断深化,人们对烧伤后脓毒症的发病机制有了新的了解.

The potential role of regulatory T cells in postburn sepsis

It has been demonstrated that severe burn per se may contribute to activation and proliferation of regulatory T cells (Treg). This characteristic phenomenon might allow Treg to function for a prolonged period of time to regulate immune response, and to induce suppression of T lymphocyte immune function. Different degrees of elevated levels of cytokines produced by Treg and activation markers on Treg surface could also be involved in the development of sepsis and fatal outcome in patients with severe burn. Thus, the regulation of Treg as a cellular therapeutic strategy might be important to the Th1/Th2 cytokine balance in burn patients complicated with sepsis.