抑制增生性糖尿病视网膜病变纤维化的研究进展

增生性糖尿病视网膜病变(PDR)的纤维增生膜形成严重危害患者的视功能,抑制纤维化的发生与发展是挽救晚期糖尿病视网膜病变患者视功能的关键.近年来,关于抑制PDR患者视网膜新生血管形成的文献报道较多,而有关抑制纤维化形成的报告并不多见.血管紧张素转换酶抑制剂、血管内皮生长因子受体拮抗剂、羟甲基戊二酰辅酶A还原酶抑制剂及糖皮质激素的应用,可以通过不同途径,不同程度地抑制纤维化的发生.因此,有必要就目前有关抑制PDR纤维增生膜形成的研究现状进行综述,旨在为治疗PDR及其纤维化的形成提供更广阔的思路和途径.

Recent advances in the studies of the inhibition of fibrosis in proliferative diabetic retinopathy

Proliferative fibrotic membranes in Proliferative diabetic retinopathy (PDR) cause severe harm to the patients' visual function. It is critical to inhibit the occurrence and development of fibrosis in order to preserve the visual function of the patients in advanced stage of diabetic retinopathy. In recent years, reports about inhibiting neovascularization in PDR are common. It is rare to find reports about inhibiting fibrosis formation. The application of angiotensin converting enzyme inhibitor, vascular endothelial growth factor receptor antagonist, HMG coenzyme A reductase inhibitors and steroids could inhibit the formation of fibrosis at varying degrees by targeting different pathways. Therefore, it is necessary to summarize the basis of current research conditions for the inhibition of the formation of proliferative fibrotic membranes in PDR, which will provide extensive ideas for the treatment of PDR and fibrosis formation.