中空多孔钛种植体复合牛骨形成蛋白的实验研究--即刻植入的组织学观察

将牛骨形成蛋白 (bovinebonemorphogeneticprotein,bBMP)与中空多孔柱状钛种植体复合形成以种植体为中心的多载体系统 ,进行骨内即刻种植 ,以探讨种植体———骨界面的骨生长代谢过程 ,并验证即刻种植的可能性。方法 :在杂种狗下颌肌建立即刻种植模型 ,于2、4、8、16、24周取材 ,进行组织学光镜和扫描电镜观察。结果结论 :新生骨逐渐长入种植体表面孔隙中 ,并与钛表面形成骨性结合 ;bBMP促进界面骨形成提前启动 ,成骨量大 ;即刻种植体周围骨缺损的修复和骨形成类似于拔牙创的愈合 ,经过适当处理 ,可形成良好骨结合而获成功。

The Test of The Titanium- Hollow Porous Cyclinder Implant Filled With Bone Morphogentic Protein--The Histological study of Immediate Implantation

Objective:To evaluate implant early reaction to bovine bone morphogenetic protein (bBMP), we implant the titanium-hollow porous cyclinder implant filled with bone morphogentic protein into the mandibule of dogs.Methods: We got tissue speciments at 2,4,6,8,16,24 weeks, use light microscopy and SEM to study the histological change of peri-implant tissue.Results and Conclusion:We find the new bone growed into the hollow porous cylinder implant, the amount of new bone is significantly larger than the control group. We regard bMP can induce the early osteogensis and synostosis.