| Effect of Radiofrequency Catheter Ablation on Calcium Channel of Ventricular Myocytes |
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| 引用本文： | 王扬淦,陆再英,赵华月,唐明,刘庆华. Effect of Radiofrequency Catheter Ablation on Calcium Channel of Ventricular Myocytes[J]. 华中科技大学学报(医学英德文版), 1995, 15(1): 1-4. DOI: 10.1007/BF02887875 |
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| 作者姓名： | 王扬淦 陆再英 赵华月 唐明 刘庆华 |
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| 作者单位： | Department of Internal Medicine，Tongji Hospital，Tongji Medical University，Wuhan |
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| 摘 要： | （王扬淦）（陆再英）（赵华月）（唐明）（刘庆华）ＥｆｆｅｃｔｏｆＲａｄｉｏｆｒｅｑｕｅｎｃｙＣａｔｈｅｔｅｒＡｂｌａｔｉｏｎｏｎＣａｌｃｉｕｍＣｈａｎｎｅｌｏｆＶｅｎｔｒｉｃｕｌａｒＭｙｏｃｙｔｅｓ￥ＷＡＮＧＹａｎｇ－ｇａｎ；ＬＵＺａｉ－ｙｉｎｇ；Ｚ...
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| 收稿时间： | 1994-09-29 |
Effect of radiofrequency catheter ablation on calcium channel of ventricular myocytes |
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| Wang Yang-gan,Lu Zai-ying,Zhao Hua-yue,Tang Ming,Liu Qing-hua. Effect of radiofrequency catheter ablation on calcium channel of ventricular myocytes[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 1995, 15(1): 1-4. DOI: 10.1007/BF02887875 |
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| Authors: | Wang Yang-gan Lu Zai-ying Zhao Hua-yue Tang Ming Liu Qing-hua |
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| Affiliation: | (1) Department of Internal Medicine, Tongji Hospital, Tongji Medical University, Wuhan |
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| Abstract: | Summary Using whole-cell patch-clamp technique, the effect of radiofrequency catheter ablation (RFCA) on calcium current (Ica) of guinea pig ventricular myocytes was examined. The radiofrequency energy delivered was 20 W× 10 s. RFCA decreased Ica apparently with the affected area reaching up to 1.2 cm from the ablation focus. In the meanwhile, the pathological lesion size resulted from RFCA was merely 0. 41 ±0. 11 cm. These findings indicate that RFCA, apart from causing tissue necrosis by heat, can affect myocyte membrane currents in a large area. This may explain why RFCA has a very high success rate with a small pathological lesion. |
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| Keywords: | patch-clamp arrhythmia ablation radiofrequency ion channel |
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