| 慢性牙周炎牙龈组织细胞凋亡及凋亡相关蛋白Caspase-3的表达 |
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| 引用本文： | 张轩,冯利,余占海,张菊梅. 慢性牙周炎牙龈组织细胞凋亡及凋亡相关蛋白Caspase-3的表达[J]. 牙体牙髓牙周病学杂志, 2011, 0(6): 325-328 |
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| 作者姓名： | 张轩 冯利 余占海 张菊梅 |
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| 作者单位： | 兰州大学口腔医学院;兰州大学基础医学院; |
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| 摘 要： | 目的:研究慢性牙周炎牙龈组织中细胞凋亡的发生情况和Caspase-3蛋白的表达,探讨其在慢性牙周炎病变发生中的意义。方法:应用脱氧核糖核苷酸末端转移酶介导的原位缺口末端标记法(TUNEL法)、免疫组织化学方法检测21例慢性牙周炎牙龈组织和21例健康牙龈组织中的细胞凋亡指数(apoptosis index,AI)及Caspase-3蛋白的表达。结果:慢性牙周炎组牙龈组织中细胞凋亡指数明显高于正常对照组(P<0.05)。与正常组相比,慢性牙周炎组牙龈组织中细胞caspase-3表达明显增强,两组间有显著性差异(P<0.05)。结论:慢性牙周炎病人牙龈组织细胞发生凋亡,且通过激活细胞凋亡信号传导途径中的Caspase-3而导致慢性牙周炎发生。
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| 关 键 词： | 慢性牙周炎 Caspase-3 细胞凋亡 |
Apoptosis in gingival tissues with chronic periodontitis and expression of related apoptosis protein Caspase-3 |
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| ZHANG Xuan,FENG Li,YU Zhan-hai,ZHANG Ju-mei. Apoptosis in gingival tissues with chronic periodontitis and expression of related apoptosis protein Caspase-3[J]. Chinese Journal of Conservative Dentistry, 2011, 0(6): 325-328 |
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| Authors: | ZHANG Xuan FENG Li YU Zhan-hai ZHANG Ju-mei |
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| Affiliation: | ZHANG Xuan*,FENG Li,YU Zhan-hai,ZHANG Ju-mei (*School of Stomatology,Lanzhou University,Lanzhou 730000,China) |
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| Abstract: | AIM: To investigate whether apoptosis exist in gingival tissues of chronic periodontitis and to examine the expression of Capase 3 in gingival tissues.METHODS: Gingival tissues from 21 periondontitis patients and 21 periodontally healthy individuals were collected,respectively.Apototic cells were detected by TUNEL staining and caspase-3 expression were determined by immunohistochemical staining SP method.RESULTS: The apoptosis index in gingival tissues of chronic periodontitis group was significantly higher... |
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| Keywords: | chronic periodentitis Caspase-3 cell apoptosis |
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