| 基质细胞衍生因子1在人炎症牙髓组织中表达的实验研究 |
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| 引用本文： | 张中兴. 基质细胞衍生因子1在人炎症牙髓组织中表达的实验研究[J]. 牙体牙髓牙周病学杂志, 2011, 0(6): 315-319,339 |
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| 作者姓名： | 张中兴 |
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| 作者单位： | 扬州市中医院口腔科; |
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| 摘 要： | 目的:研究基质细胞衍生因子1(Stromal cell-derived factor-1,SDF-1)及其受体CXCR4在人炎性牙髓组织中的表达,探讨SDF-1/CXCR4轴在牙髓炎症发生发展中的可能作用。方法:采用免疫组织化学染色的方法检测SDF-1和CXCR4阳性细胞在健康、炎症牙髓组织中的分布情况。以实时荧光定量RT-PCR方法检测SDF-1mRNA在健康和炎症牙髓中的表达。结果:炎性牙髓中SDF-1、CXCR4主要分布于炎性细胞、成牙本质细胞和微血管内皮细胞。而正常组牙髓少见SDF-1、CXCR4阳性细胞。炎性牙髓中SDF-1mRNA的表达较健康牙髓显著增强。结论:与正常牙髓相比,炎性牙髓组织中SDF-1、CXCR4阳性细胞明显增多。炎性牙髓中SDF-1表达水平明显上调。SDF-1/CXCR4轴可能参与了牙髓炎症损伤和修复过程。
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| 关 键 词： | 牙髓 基质细胞衍生因子1 CXCR4 免疫组织化学 |
Expression of Stromal cell-derived factor-1 in human inflamed dental pulp tissue |
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| ZHANG Zhong-xing. Expression of Stromal cell-derived factor-1 in human inflamed dental pulp tissue[J]. Chinese Journal of Conservative Dentistry, 2011, 0(6): 315-319,339 |
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| Authors: | ZHANG Zhong-xing |
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| Affiliation: | ZHANG Zhong-xing (Hospital of Traditional Chinese Medicine,Yangzhou 225009,China) |
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| Abstract: | AIM: To investigate the expression of Stromal cell-derived factor-1(SDF-1) and CXCR4 in human inflammed dental pulps and to explore the role of SDF-1/CXCR4 axis in pulpal inflammation.METHODS: Inflamed dental pulp tissues were obtained from extracted teeth that showed spontaneous pain and/or lingering pain in response to cold and/or heat stimulus,and normal dental pulp tissues were obtained from healthy noncarious teeth.Distribution of SDF-1-positive and CXCR4-positive cells in the dental pulp tissues was i... |
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| Keywords: | dental pulp stromal cell derived factor-1 CXCR4 immunohistochemistry |
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