| 纳米级羟基磷灰石梯度涂层植入体骨结合的研究 |
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| 引用本文： | Wang Y,Tan YB,Yang QM,Deng LF,Zeng SX. 纳米级羟基磷灰石梯度涂层植入体骨结合的研究[J]. 中华外科杂志, 2005, 43(20): 1336-1339 |
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| 作者姓名： | Wang Y Tan YB Yang QM Deng LF Zeng SX |
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| 作者单位： | 1. 200025,上海市伤骨科研究所,上海第二医科大学附属瑞金医院骨科
2. 中国科学院上海硅酸盐研究所 |
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| 基金项目： | 上海市纳米专项资助项目（0144nm064） |
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| 摘 要： | 目的 研究纳米级羟基磷灰石梯度涂层植入体的骨结合情况。方法在Beagle犬股骨髁植入纳米级羟基磷灰石梯度涂层栓、普通级羟基磷灰石栓和钛合金（Ti-6AL-4V）栓,4、8和12周比较植入体-骨界面的组织学、骨动力学参数并进行电镜观察。结果纳米级羟基磷灰石梯度涂层组的降解速度慢于普通级羟基磷灰石组,骨动力学参数和成骨细胞形态均优于对照组。结论纳米级羟基磷灰石梯度涂层植入体优于普通级羟基磷灰石涂层植入体。
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| 关 键 词： | 羟基磷灰石 成骨细胞 纳米级 |
| 收稿时间： | 2004-09-14 |
| 修稿时间： | 2004-09-14 |
Experimental study on the osseointegration of nanophase hydroxyapatite biograde-coated implants |
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| Wang Yi,Tan Yan-bin,Yang Qing-ming,Deng Lian-fu,Zeng Shao-xian. Experimental study on the osseointegration of nanophase hydroxyapatite biograde-coated implants[J]. Chinese Journal of Surgery, 2005, 43(20): 1336-1339 |
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| Authors: | Wang Yi Tan Yan-bin Yang Qing-ming Deng Lian-fu Zeng Shao-xian |
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| Affiliation: | Department of Orthopaedic, Ruijn Hospital, Shanghai Second Medical University, Shanghai 200025, China |
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| Abstract: | Objective To study the osteointegration of the nanophase hydroxyapatite biogradecoated implants and host bone. Methods Nanophase hydroxyapatite biograde-coated implants, hydroxyapatite biograde-coated implants and noncoated Ti-6Al-4V implants were inserted into both femoral of Beagle canines the tissue response, dynamic osteogensis and SEM were studied at 4, 8 and 12 weeks. Results The degradation of nanophase hydroxyapatite was slower than hydroxyapatite, dynamic osteogensis and the form of osteoblast were better than the control groups. Conclusion The biological reaction of Nanophase hydroxyapatite biograde-coated implants is better than hydroxyapatite coated implant. |
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| Keywords: | Hydroxyapatite Osteoblasts Nanophase |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ |
