二甲双胍联合荷丹片对非酒精性脂肪性肝病生化指标的影响

目的探讨二甲双胍联合荷丹片治疗非酒精性脂肪性肝病（NAFLD）的疗效。方法将100例NAFLD患者随机分为实验组和对照组,每组50例。实验组采取二甲双胍联合荷丹片的治疗方法,对照组采取荷丹片单独治疗。结果治疗后,两组病情均有一定程度的好转。与对照组相比,实验组AST、ALT、TG、TC等指标明显改善,总有效率为94%（P〈0.05）。两组不良反应比较,差异无统计学意义。结论二甲双胍联合荷丹片治疗NAFLD较单用荷丹治疗效更佳,值得临床推广。

Effect of metformin combined with hedan tablets on biochemical indicators of nonalcoholic fatty liver disease

Objective To discuss the effect of metformin combined with hedan tablets in the treatment for non-alcoholic fatty liver disease （NAFLD）. Methods 100 NAFLD patients were randomly divided into experimental group and control group,50 cases in each group. Patients of experimental group were given metformin combined with hedan tablets, and control group was only given hedan tablets. Results After treatment, the condition of both experimental group and control group had certain improvement. Compared with control group, the AST, ALT, TG, TC and other indicators of experimental group were improved more effectively. The total effective rate of experimental group was better than that of control group（94% vs. 76% ,P 〈 0. 05 ）. The adverse reactions had no singnificant difference between the two groups. Conclusion Metformin combined with hedan tablets in the treatment for non-alcoholic fatty liver disease is a better way than single use, and it is worthy of promotion.