Effects of a 5-lipoxygenase-activating protein inhibitor on biomarkers associated with risk of myocardial infarction: a randomized trial |
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Authors: | Hakonarson Hakon Thorvaldsson Sverrir Helgadottir Anna Gudbjartsson Daniel Zink Florian Andresdottir Margret Manolescu Andrei Arnar David O Andersen Karl Sigurdsson Axel Thorgeirsson Gestur Jonsson Asgeir Agnarsson Uggi Bjornsdottir Halldora Gottskalksson Gizur Einarsson Atli Gudmundsdottir Hrefna Adalsteinsdottir Asdis E Gudmundsson Kolbeinn Kristjansson Kristleifur Hardarson Thordur Kristinsson Arni Topol Eric J Gulcher Jeffrey Kong Augustine Gurney Mark Thorgeirsson Gudmundur Stefansson Kari |
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Institution: | Decode Genetics Inc, Reykjavik, Iceland (Drs Hakonarson, Helgadottir, Gudbjartsson, Zink, Manolescu, Gudmundsson, Kristjansson, Gulcher, Kong, Gurney, and Stefansson, Mr Thorvaldsson, and Mss Andresdottir and Adalsteinsdottir); Landspitali University Hospital, Reykjavik, Iceland (Drs Arnar, Andersen, Sigurdsson, Gestur Thorgeirsson, Jonsson, Agnarsson, Bjornsdottir, Gottskalksson, Hardarson, Kristinsson, and Gudmundur Thorgeirsson); Icelandic Heart Association, Reykjavik (Drs Einarsson and Gudmundsdottir); and Cleveland Clinic Foundation, Cleveland, Ohio (Dr Topol). |
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Abstract: | Context Myocardial infarction (MI) is the leading cause of death in the world. Variants in the 5-lipoxygenaseactivating protein (FLAP) gene are associated with risk of MI. Objective To determine the effect of an inhibitor of FLAP on levels of biomarkers associated with MI risk. Design, Setting, and Patients A randomized, prospective, placebo-controlled, crossover trial of an inhibitor of FLAP (DG-031) in MI patients who carry at-risk variants in the FLAP gene or in the leukotriene A4 hydrolase gene. Of 268 patients screened, 191 were carriers of at-risk variants in FLAP (87%) or leukotriene A4 hydrolase (13%). Individuals were enrolled in April 2004 and were followed up by designated cardiologists from a university hospital in Iceland until September 2004. Interventions Patients were first randomized to receive 250 mg/d of DG-031, 500 mg/d of DG-031, 750 mg/d of DG-031, or placebo. After a 2-week washout period, patients received DG-031 if they had received placebo first or placebo if they had received DG-031 first. Treatment periods lasted for 4 weeks. Main Outcome Measures Changes in levels of biomarkers associated with risk of MI. Results In response to 750 mg/d of DG-031, production of leukotriene B4 was significantly reduced by 26% (95% confidence interval CI], 10%-39%; P = .003) and myeloperoxidase was significantly reduced by 12% (95% CI, 2%-21%; P = .02). The higher 2 doses of DG-031 produced a nonsignificant reduction in C-reactive protein (16%; 95% CI, 2% to 31%; P = .07) at 2 weeks. However, there was a more pronounced reduction (25%; 95% CI, 5%-40%; P = .02) in C-reactive protein at the end of the washout period that persisted for another 4 weeks thereafter. The FLAP inhibitor DG-031 was well tolerated and was not associated with any serious adverse events. Conclusion In patients with specific at-risk variants of 2 genes in the leukotriene pathway, DG-031 led to significant and dose-dependent suppression of biomarkers that are associated with increased risk of MI events. |
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