甲状腺肿瘤组织中c-myc和PCNA的表达及意义

目的 探讨c—myc和增殖细胞核抗原(PCNA)在甲状腺良、恶性肿瘤组织中的表达及其诊断意义。方法 应用免疫组化法，检测28例甲状腺腺瘤和30例甲状腺癌组织中c—myc和PCNA的表达。结果c—myc和PCNA在腺癌组织中阳性表达率分别为90．0％(27/30)和80．0％(24／30)，显著高于腺瘤组织分别为42．9％(12/28)，53．6％(15/28)，P＜0．05。腺瘤组织中c—myc主要表达于细胞核，阳性率为83．3％；而腺癌组织则多表达于细胞质，阳性率为88．9％。甲状腺肿瘤中c—myc表达和PC—NA表达无相关性。结论 检测c—myc、PCNA的表达有助于甲状腺肿瘤良恶性的鉴别诊断；甲状腺肿瘤中c—myc表达与PCNA表达无协同作用。

Diagnostic Value of C-Myc and PCNA in Thyroid Neoplasm

Objective To study the diagnostic value of c Myc and proliferating cell nuclear antigen(PCNA)in the benign and malignant thyroid neoplasms.Methods Expressions of C Myc and PCNA were detected in 28 thyroid adenomas and 30 thyroid carcinomas by immunohistochemical method.Results The positive rate of c Myc and PCNA was significantly higher in thyroid carcinoma than those in thyroid adenoma(90.0% and 80.0% VS 42.9% and 53.6%,respectively)( P <0.05).C Myc was mainly located in nuclear of tumor cells in thyroid adenomawith a positive rate of 83.3%.,while c Myc was mainly located in cytoplasm of tumor cells in thyroid carcinoma,with a positive rate of 88.9%.No correlation was observed between c Myc and PCNA expression in thyroid neoplasm.Conclusion The detection of c My and PCNA is valuable to differentiate between benign and malignant neoplasm of thyroid gland,and there is no synergy between c Myc and PCNA expression in thyroid neoplasm.