三种方法治疗未破裂卵泡黄素化综合征的疗效分析

目的 比较3种方法治疗未破裂卵泡黄素化综合征（LUFS）疗效。方法 将34个病例56个治疗周期随机分成3个治疗组：A组（HCG组），B组（单次GnRH—a组），C组（GnRH—a＋HCG组），观察3组患者的妊娠率，排卵率，并分别于HCG／达必佳注射日及排卵后7日抽取外周血测LH，P，观察各组有无差异。结果 3种治疗方法的排卵率有统计学差异（P〈0．05），C组的排卵率显著高于B组，A组。而3组的妊娠率则无明显差异（P〉0．05）。HCG／达必佳注射日3组血LH有统计学差异（P〈0．05），C组低于A组与B组，而血P值则3组之间无统计学差异（P〉0．05）。排卵后7日血P值3组之间亦有统计学差异（P〈0．05），A组高于C组，C组高于B组。结论 GnRH—a＋HMG方案能有效的降低HCG注射日LH值。提高LUFS患者的排卵率，但妊娠率无明显改善。

A research in effective protocol of treating luteinized unruptured ovarian follicle syndrome

Objective： To research in effective protocol of treating luteinized unruptured ovarian follicle sydrome. Methods： 34 cases of LUFS who were treated for 56 treatment cycles were devided into 3 groups. Three groups including group A （HCGgroup） , group B （Triptorelin group） , group C （Triptoreline ＋ HCG group） were analyzed. The ovulation rate, pregnancy rate of 3 groups were recorded and compared. Radio - immunoassay was performed to measure the serum LH, P levels on day of HCG/GnRH - a administration and on 7days after ovulation. Results： Ovulation rates were significantly deviated （ P 〈 0. 05）. The ovulation rate of group C was significantly higher than group A and group B. Clinical pregnancy rates were not significantly different （ P 〉 0. 05 ）. The LH level of group C on day of HCG/GnRH - a administration is significantly lower than that of group B and group C. The P level on day of HCG/GnRH - a administration is insignificantly deviated. The P level on 7 days after ovulation is significantly different, group A 〉 group B 〉 group C. Conclusion： GnRH- a can lower the LH level and raise the ovulation rate efficiently , but can＇t improve the pregnancy rate. The possible reason is inadequate luteal function induced by GnRH -a.