Protracted venous infusion 5-fluorouracil and interferon-{alpha} in advanced and refractory colorectal cancer |
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| Authors: | Findlay M; Hill A; Cunningham D; Norman A; Nicolson M; Ford H; Husband J; Evans C; Carter R |
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| Institution: | The CRC Section of Medicine and GI Unit, Royal Marsden Hospital and Institute of Cancer Research Downs Road Sutton, Surrey, U.K. |
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| Abstract: | BACKGROUND: The management of patients with advanced colorectal cancer remainsdependent on the optimal use of 5-Fluorouracil (5-FU). Enhanced5-FU activity can be achieved by either adding a modulator orby altering the administration schedule, in particular usinga protracted venous infusion. Based on encouraging phase IIdata using bolus 5-FU and interferon- |
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