血清磷脂酶A2活性与精神分裂症的关系

目的： 探讨中国北方汉族人群血清磷脂酶A2（PLA2）活性与精神分裂症的关系。方法：采用酸碱滴定法检测中国北方汉族115例精神分裂症患者(病例组)和115例正常健康人(对照组)血清PLA2的活性。结果：病例组血清PLA2活性水平［（45.28±7.17）U］明显高于对照组［（26.92±3.81）U］（P<0.001）。10～20岁和60岁以上组的血清PLA2活性水平病例组与对照组比较差异无显著性（P>0.05）；21～30岁、31～40岁、41～50岁和51～60岁各年龄段的血清PLA2活性水平病例组高于对照组（P<0.05）。结论：血清PLA2的活性增高可能与精神分裂症的发病有关联。

Association between serum phospholipase A2 activity and schizophrenia

Objective To investigate the association between serum phospholipase A2 (PLA2) activity and schizophrenia in Han population in North China.Methods The acid-base titration method was conducted to examine the serum PLA2 activity in 230 subjects including 115 patients with schizophrenia (case group) and 115 matched healthy controls(control group).Results The serum PLA2 activity level in case group was significant higher than that in controls(P<0.001).In subjects aged 10 to 20 and above 60 years,there were no significant differences of serum PLA2 activity between cases and controls(P>0.05); in other subjects aged 21 to 30,31 to 40,41 to 50,51 to 60 years,there were significant differences in distribution of serum PLA2 activity between cases and controls(P<0.05).Conclusion The augmentation of serum PLA2 activity may be associated with the onset of schizophrenia.