特布他林联合布地奈德雾化吸入治疗婴儿类百日咳综合征临床疗效分析

目的探讨特布他林联合布地奈德雾化吸入治疗婴儿类百日咳综合征的临床疗效。方法80例类百日咳综合征患儿,随机分为观察组与对照组,每组40例。对照组采用抗感染等综合性治疗,观察组在对照组的基础上采用特布他林联合布地奈德雾化吸入治疗。比较两组患儿的痉咳缓解时间、肺部阳性体征消失时间、住院时间、住院费用及治疗效果,观察组患儿的不良反应发生情况。结果观察组患儿的痉咳缓解时间、肺部阳性体征消失时间、住院时间分别为(6.89±1.01)、(7.29±1.32)、(10.30±1.11)d,均短于对照组的(8.99±1.35)、(8.79±1.03)、(12.23±1.01)d,住院费用(3026.0±222.0)元少于对照组的(3603.0±302.2)元,差异均有统计学意义(P<0.05)。治疗后,观察组患儿的治疗总有效率为92.5%,高于对照组患儿的75.0%,差异有统计学意义(P<0.05)。观察组有极个别患儿于刚开始雾化时出现咳嗽加重、烦躁、哭闹不安、面色潮红,暂停雾化后予拍背吸痰,咳嗽症状缓解后继续予雾化治疗,均未再出现明显不适。结论采用特布他林联合布地奈德雾化吸入治疗婴儿类百日咳综合征临床效果显著,无明显不良反应,安全性高,值得在临床中推广应用。

Clinical effect analysis of terbutaline combined with budesonide for inhalation in the treatment of infantile pertussis-like syndrome

Objective To discuss the clinical efficacy of terbutaline combined with budesonide for inhalation in the treatment of infantile pertussis-like syndrome.Methods A total of 80 infantile with pertussislike syndrome were randomly divided into observation group and control group,with 40 cases in each group.The control group received comprehensive therapy of anti infection,and the observation group received terbutaline combined with budesonide for inhalation on the basis of the control group.The spasmodic cough remission time,disappearance time of lung positive signs,hospitalization time,hospitalization cost and therapeutic effect was compared between the two groups,and the occurrence of adverse reactions was observed.Results The spasmodic cough remission time,disappearance time of lung positive signs and hospitalization time were(6.89±1.01),(7.29±1.32)and(10.30±1.11)d,which were shorter than(8.99±1.35),(8.79±1.03)and(12.23±1.01)d in the control group,and hospitalization costs was(3026.0±222.0)yuan was less than(3603.0±302.2)yuan.Their difference was statistically significant(P<0.05).After treatment,the total effective rate of treatment was 92.5%,which was higher than 75.0%in the control group,and the difference was statistically significant(P<0.05).In the observation group,there were very few children who had aggravated cough,irritability,crying,and flushing at the beginning of atomization.After the suspension of atomization,the infants were given back pat and sputum aspiration,and after the cough symptoms were relieved,the infants were given atomization treatment,and no obvious discomfort occurred again.Conclusion Terbutaline combined with budesonide for inhalation shows remarkable clinical effect in the treatment of infantile pertussis-like syndrome without obvious adverse reactions.It is safe and is worthy of clinical promotion and application.