| D-半乳糖和铝联合应用诱导大脑产生阿尔茨海默病样损伤(英文) |
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| 引用本文： | 肖飞,李晓光,张晓裕,候军代,林炼峰,高勤,罗焕敏. D-半乳糖和铝联合应用诱导大脑产生阿尔茨海默病样损伤(英文)[J]. 中国神经科学杂志, 2011, 0(3) |
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| 作者姓名： | 肖飞 李晓光 张晓裕 候军代 林炼峰 高勤 罗焕敏 |
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| 作者单位： | 暨南大学医学院药理学系;暨南大学脑科学研究所;暨南大学-香港大学脑功能与健康联合实验室; |
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| 基金项目： | supported by National Natural Science Foundation of China (No. 30271502) |
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| 摘 要： | 目的 D-半乳糖能制作亚急性衰老模型,铝具有神经毒性,但两者联合应用的作用未见报道。本研究旨在探讨D-半乳糖和铝联合应用对动物学习记忆、脑内生化和病理的影响,以及与单独应用D-半乳糖或铝所制作的动物模型相比较。方法昆明小鼠单独皮下注射D-半乳糖、单独灌胃铝以及既注射D-半乳糖又灌胃铝,制作动物模型,共给药8周或10周,10周后再停用药物6周。在第8、10、16周末,采用Morris水迷宫检测小鼠学习记忆能力,生化学方法检测脑内乙酰胆碱能系统,免疫组化法检测老年斑和神经原纤维缠结的形成。结果联合应用D-半乳糖和铝后,小鼠表现出明显的学习和记忆力障碍,并且其脑内乙酰胆碱水平降低,乙酰胆碱转移酶和胆碱脂酶活性下降,出现老年斑样和神经原纤维缠结样病理改变。停止给药后,其行为学、生化和病理改变至少能维持6周以上。结论小鼠中D-半乳糖和铝联合应用是一个有效的非转基因阿尔茨海默病(Alzheimer’sdisease,AD)模型,可用于AD病理研究和相关治疗药物的评价。
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| 关 键 词： | 阿尔茨海默病 脑改变 D-半乳糖 铝 神经退行性疾病 动物模型 |
Combined administration of D-galactose and aluminium induces Alzheimer-like lesions in brain |
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| Fei XIAO,Xiao-Guang LI,,,Xiao-Yu ZHANG,Jun-Dai HOU,Lian-Feng LIN,Qin GAO,Huan-Min LUO,. Combined administration of D-galactose and aluminium induces Alzheimer-like lesions in brain[J]. Neuroscience Bulletin, 2011, 0(3) |
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| Authors: | Fei XIAO Xiao-Guang LI Xiao-Yu ZHANG Jun-Dai HOU Lian-Feng LIN Qin GAO Huan-Min LUO |
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| Affiliation: | Fei XIAO1,Xiao-Guang LI2,3,*,Xiao-Yu ZHANG1,Jun-Dai HOU1,Lian-Feng LIN1,Qin GAO2,Huan-Min LUO1,2,3 1Department of Pharmacology,School of Medicine,Jinan University,Guangzhou 510632,China 2Institute of Brain Science,China 3Joint Laboratory for Brain Function and Health,Jinan University and The University of Hong Kong,China |
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| Abstract: | Objective It has been reported that D-galactose (D-gal) can model subacute aging, and aluminum (Al) acts as a neurotoxin, but combined effects of them have not been reported. The present work aimed to reveal the effect of combined administration of D-gal and Al in mice and compare the effect of D-gal treatment with that of Al treatment. Methods Al was intragastrically administered and D-gal was subcutaneously injected into Kunming mice for 10 consecutive weeks. Learning and memory, cholinergic systems, as w... |
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