Effects of gonadotrophin on resistance to Listeria monocytogenes infection in mice.

It was demonstrated that exogenous GH suppressed the resistance to L. monocytogenes infection in Listeria resistant C57Bl/6 and susceptible A/J mice. However, different parameters of the immunological reaction to Listeria were affected by GH treatment in these mouse strains. In C57Bl/6 mice GH decreased accumulation of macrophages at the inflammatory site. On the contrary, a depression of anti-listerial activity of the phagocytes and a reduction of DTH reaction to Listeria antigen was demonstrated in GH treated A/J mice.