Antitubercular constituents from the stem wood of Cinnamomum kotoense |
| |
| Authors: | Chen Fu-Chi Peng Chien-Fang Tsai Ian-Lih Chen Ih-Sheng |
| |
| Affiliation: | Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan 807, Republic of China. |
| |
| Abstract: | Five new compounds, kotolactone A (1), kotolactone B (2), secokotomolide (3), kotodiol (4), and 2-acetyl-5-dodecylfuran (5), and 36 known compounds have been isolated from the stem wood of Cinnamomum kotoense. The structures of these new compounds were determined by means of spectroscopic analysis. The known butanolides, isoobtusilactone A (6) and lincomolide B (7), showed in vitro antitubercular activities with MIC values of 22.48 and 10.16 microM, respectively, against Mycobacterium tuberculosis 90-221387. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
