| 齐拉西酮与喹硫平治疗精神分裂症疗效和安全性比较 |
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| 引用本文： | 马兆峰. 齐拉西酮与喹硫平治疗精神分裂症疗效和安全性比较[J]. 山东医学高等专科学校学报, 2009, 31(3): 163-166 |
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| 作者姓名： | 马兆峰 |
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| 作者单位： | 临沂市精神卫生中心,山东临沂,276005 |
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| 摘 要： | 目的 比较齐拉西酮与喹硫平治疗精神分裂症的疗效和安全性.方法 对符合CCMD-3和ICD-10精神分裂症的诊断标准的80例精神分裂症患者,根据随机对照方案分别使用齐拉西酮和喹硫平治疗,疗程共8周.采用阳性症状和阴性症状量表(PANSS)、临床总体印象量表(CGI)进行疗效评定,采用不良反应症状量表(TESS)进行副反应评定.结果 治疗8周后,齐拉西酮组显效率为67.5%,有效率为92.5%;喹硫平组显效率为62.5%,有效率为90.0%.两种药物疗效差异无显著性(P>0.05).两种药物的主要副反应均为头痛、头晕等等,两组间副反应发生率无显著性差异(P>0.05),副反应的严重程度喹硫组高于齐拉西酮组.结论 齐拉西酮和喹硫平对精神分裂症疗效相当.两种药物均为疗效好、安全性高,不良反应轻的抗精神病药,有利于提高患者的生活质量及用药依从性.
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| 关 键 词： | 齐拉西酮 喹硫平 精神分裂症 疗效 安全性 |
THE COMPARATION OF EFFECTS AND SECURITY OF ZIPRASIDONE AND QUETIAPINE IN THE TREATMENT OF SCHIZOPHRENIA |
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| MA Zhao-feng. THE COMPARATION OF EFFECTS AND SECURITY OF ZIPRASIDONE AND QUETIAPINE IN THE TREATMENT OF SCHIZOPHRENIA[J]. Journal of Shandong Medical College, 2009, 31(3): 163-166 |
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| Authors: | MA Zhao-feng |
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| Affiliation: | Linyi City Mental Health Center;Linyi;China 276005 |
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| Abstract: | Objective To compare the effects and security of ziprasidone and quetiapine in the treatment of schizophrenia.Methods 80 cases with schizophrenia who meet with the CCMD-3 and ICD-10 diagnostic criteria for schizophrenia were treated with ziprasidone and quetiapine for 8 weeks,according to the use of random controlled program.Positive and negative symptom scale(PANSS)and Clinical Global Impression Scale(CGI)were used for efficacy evaluation and adverse reactions Symptom Scale(TESS) for assessment of side eff... |
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| Keywords: | Ziprasidone Quetiapine Schizophrenia Efficacy Security |
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