立体定向放射治疗肺癌的临床探讨

30例肺癌患者，鳞癌26例，腺癌4例；立体照射单次剂量5～10Gy，隔日一次，共4～8次，5～6个弧形或非共面适形固定野照射，总量26～42Gy。放疗后2～3个月复查CT，PR8例、PR18例、NR4例，总有效率为86.7%，中位生存期12个月，1年局控率86.7%。Kaplan-Meier生存率计算，1年和两年生存率分别为84.6%和61.92%。结果提示，立体定向放射治疗肺癌可起到良好的姑息或根治性治疗作用。配合常规处照射，在不增加近期放疗反应和并发症的同时，可增加靶区剂量，缩短疗程，提高肿瘤控制和近期疗效。

CLINICAL TREATMENT OF LUNG CANCER BY STEREOTATIC RADIOTHERAPY COMBINED WITH EXTERNAL IRRADIATION

26 cases were histologically confirmed to be patients with squamous cell carcinoma, 4 cases to be patients with adenocarcinoma. The majority of the patients received stereotatic radiotherapy on the basis of external radiation. The single dose for stereotatic radiation was 5～10Gy, once every two days, 4～8 fractions, the total dose was 26～42 Gy by using 5～6 non-coplanar stationary beams or arc radiation. The patients′ CT was checked 2～3 months after treatment, there were 8 cases of CR( 26.7％), 18 cases of PR(60％),4 case of NR (13.3％).The median survival time was 12 months and the survival of 1 year and 2 years was 84.％ and 61.2% (using Kaplan-Meier methods). The total effective rate was 86.7%. The results suggested that stereotatic radiotherapy (SRT) is effective for lung cancer at palliative and radical treatment. Combined with external irradiation, it can increase the doses of target and shorten the course of treatment.