西咪替丁、维生素C小鼠体内抗狂犬病效果研究

目的 旨在寻找一种安全有效的抗狂犬病毒药物,为狂犬病的治疗提供参考.方法 采用小鼠动物模型的随机对照实验,实验组腹腔注射0.4 mg/只、3.2 mg/只西咪替丁及50 mg/只维生素C,用生存分析比较实验组和对照组生存差异,评价药物的疗效.结论 0.4 mg/只和3.2 mg/只的西咪替丁药量治疗狂犬病毒感染的小鼠,实验组和对照组生存率均无显著统计学差异(P>0.05);维生素C 50 mg/只剂量经腹腔给药,其实验组与对照组生存率也无显著的统计学差异.结论在小鼠狂犬病模型中并没有发现西咪替丁及维生素C具有抗狂犬病毒的作用,目前仍然没有单一有效的抗狂犬病毒药物.

The screen of anti-rabies Virus drug in mouse models

Objective To find a safer and more effective mothod to cure rabies, and provide some reference to other researchers. Methods The rabies infection model made by mice was applied, and mice were randomly divided into experimental group and control group. Two doses of cimetidine which were 0. 4 microgram and 3.2 microgram and 50 microgram vitamin C were ihtraperitoneal injection for each infected rabies virus. The survival difference between two groups was compared with survival analysis to test the efficacy of drugs. Results There was no significant difference between the 0.4 microgram group, 3. 2 microgram group and control group. There was either no significant difference between 50 microgram vitamin C group and control group (P > 0.05 ). Conclusion There is no significant effect against rabies virus in mice models using cimetidine and vitamin C. No effective medicine is. found in single antiviral drug treatment.