不同化疗方案对晚期非小细胞肺癌的疗效分析

目的探讨不同化疗方案对晚期非小细胞肺癌的疗效。方法161例晚期非小细胞肺癌患者分别用四组不同的方案化疗，MVP40例，NPH6例，CP45例．TP40例，四组患者基线资料具有可比性。结果MVP有效率44．2％，肿瘤控制率73％；NP有效率49．7%．肿瘤控制率86．4％；GP有效率55％，肿瘤控制率92．3％；TP有效率60．5％，肿瘤控制率93．7％。四种方案有效率比较无统计学差异（P〉0．05），肿瘤控制率比较有统计学差异（P〈0．05）。结论四种化疗方案对晚期非小细胞肺癌均有效，但TP方案肿瘤控制率高．化疗副反应轻，可作为晚期NSCLC患者首选方案。

Analyses of Therapeutic Effects using Four Chemotherapeutic Methods on Advanced Non-small Cell Lung Cancer

Objective To analyze the therapeutic efficacy of four different ehcmotherapies on advanced non-small celt lung cancer （NSCLC）. Methods out of 161 NSCLC patients, 40 were given MVP regimen, 36 were given NP regimen, 45 were given GP regimen, and 40 were given TP regimen. There existed comparability of data among the regimens. Results The overall response rates and tumor control rates for chcmotherapies were as follows： the overall response rates were 44.2% for MVP, 49.7% for NR, 55% for GP, 60.5% for TP; the tumor control rates were 73.0%, 86.4% , 92.3% and 93.7% , respectively. There were not significantly statistical differences in the overall response rates among the four different chemotherapies （ P 〉 0.05 ）, but the significantly statistical differences in the tumor control rates were found （ P 〈 0.05 ）. Conclusion The four chemotherapies, i.e. MVP, NP, GP and riP regimens, are effective therapeutic methods to advanced NSCLC. The chemotherapy with TP regimen is superior to the others in terms of tumor control rates and side effect. It is thus can he the first choice of threatment for NSCLC patients.