新生儿经皮测胆红素的局限性

目的探讨经皮测胆红素的局限性。方法同时采集374例黄疸足月儿经皮测胆红素和血清总胆红素值,并对上述两指标进行正态分布检验和直线相关分析。结果374例足月儿经皮测胆红素、血清总胆红素两指标均服从正态分布（P〉0.05）。经皮测胆红素与血清总胆红素之间呈正相关,相关系数（r=0.76,P〈0.01）。将数据进一步划分,当血清总胆红素水平〈290.7μmol/L时,两者的线性相关较好,r=0.7;但当血清总胆红素水平≥290.7μmol/L时,两者的线性相关减弱,r=0.46。结论经皮测胆红素与血清总胆红素总体上呈正相关,特别是对轻、中度黄疸,但对较重的黄疸,两者相关性减弱,提示经皮测胆红素适合作为筛查高胆红素血症的指标,在决定治疗时,尤其对较重的黄疸,应以血清总胆红素为标准。

Limitation of Transcutaneous Bilirubin Measurement in Neonates

Objective To study the limitation of transcutaneous bilirubin （TcB） measurement in neonates. Methods A total of 374 full-term newborns with neonatal hyperbilirubinemia were enrolled into this study. The relationship between the TcB measurement and serum bilirubin （SBR） was studied. Results The TcB measurement and SBR in the 374 full-term newborns belonged to normal distribution （P 〈 0.05）. There was a correlation between TcB measurement and SBR （r = 0.76, P 〈 0.01 ）, When SBR was lower than 290.7μmol/L, the correlation was strong （ r = 0.70 ） , but when it was equal to or higher than 290.7μmol/L, the correlation was lessened （ r = 0.46 ）. Conclusion TcB measurement is a useful clinical screening tool to the evaluation of the risk of newborn hyperbilirubinemia. But as for the patients with the clinically significant jaundice, SBR should be measured and the treatment should be administered on the basis of its measurement.