复方血竭制剂与5-氨基水杨酸在溃疡性结肠炎临床维持缓解治疗中的疗效比较

目的比较复方血竭灌肠液及口服5-氨基水杨酸（SASP）在溃疡性结肠炎（UC）临床维持缓解治疗中的疗效。方法以血竭、白芨为原料制备复方血竭灌肠液,对51例UC患者（血竭组）进行灌肠治疗6个月;SASP组给予SASP1.5g1次/d口服维持6个月,比较两组患者的复发率及治疗中的副作用。结果血竭组和SASP组疗效间差别无显著性意义（P〉0.05）;血竭组消化道反应、血液系统毒性、肝肾功能损害明显小于对照组（P〈0.01）。结论复方血竭灌肠可用于高危患者及SASP治疗无效者的维持治疗方案。

Evaluation on Compound Dracorhodin Enema and Sulfasalazine in Maintenance Treatment for Clinical Remission of Ulcerative Colitis

Objective To compare the clinical efficacy of liquid compound dracorhodin enema and sulfasalazine in the maintenance treatment for remission of ulcerative colitis （UC）. Methods Dracorhodin and bletilla striata were compounded into enema for the preparation of treatment, which was then administered to 51 patients of UC （dracorhodin group） for six months. Oral sulfasalazine （1.5 g per day） were meanwhile given to another group of patients （control group）. The curative effects were evaluated by comparing the recurrence rates and the side-effects between the two groups. Results Difference in effect between the dracorhodin group and the control group was not significant （P〉0.05）. Gastrointestinal reaction, blood system toxicity, and liver and kidney dysfunction were significantly less in the dracorhodin group than in the control group （P〈0.01）.Conclusion Compound dracorhodin enema can be used for the treatment of the high-risk patients and of the patients who have no responses to sulfasalazine.