| 狗慢性膝关节炎症期滑膜组织中细胞因子的表达 |
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| 引用本文： | 刘虎,;蒋京京,;田谋利,;宋哲明,;袁红斌. 狗慢性膝关节炎症期滑膜组织中细胞因子的表达[J]. 解放军医学高等专科学校学报, 2008, 0(2): 178-180 |
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| 作者姓名： | 刘虎, 蒋京京, 田谋利, 宋哲明, 袁红斌 |
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| 作者单位： | [1]解放军第二军医大学上海长征医院麻醉科,上海200003 |
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| 基金项目： | 本课题受军队“十一五”面上项目（06MB223）;长征医院“三重三优”人才建设基金资助. |
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| 摘 要： | 目的研究狗慢性膝关节炎症期滑膜组织中各种细胞因子（TNF-α,IL-1β,IL-6,IL-10）表达水平。方法Beagle狗17条,分为正常组（n=8）和慢性非感染性炎症组（n=9）。分别取其膝关节滑膜组织,采用ELISA方法检测滑膜组织中各种细胞因子的表达水平。结果与正常组相比,慢性非感染性炎症组滑膜组织内IL-1β、IL-6浓度显著增高（P〈0.05）,TNF-α、IL-10浓度无明显变化（P〉0.05）。结论慢性非感染性炎症期,狗膝关节滑膜组织中IL-1β、IL-6表达显著增加。
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| 关 键 词： | BEAGLE犬 炎症 膝关节 肿瘤坏死因子 白细胞介素 |
Cytokines in Chronic Inflamed Knee Joint Synovium Tissue of Dogs |
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| Affiliation: | Liu Hu, Jiang Jing-jing, Tian Mou-li, Song Zhe-ming, Yuan Hong-bin ( Department of Anesthesiology, Changzheng Hospital of Second Military Medical University, Shanghai 200003, China) |
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| Abstract: | Objective To examine the changes in some cytokines （ TNF-α, IL-1β, IL-6, IL-10） in chronic inflamed knee joint synovium tissue of dogs. Methods Knee joint synovium tissue was taken from nine Beagle dogs with chronic knee arthritis and eight dogs with normal knee joints. Cytokines were detected using ELISA. Results The expression of IL-1β and IL-6 in the chronic inflamed group was significantly higher than that in the normal group （ P 〈 0.05 ）. Conclusion Chronic inflammation enhances the expression of IL-1βand IL-6 in knee joint synovium tissue of dogs. |
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| Keywords: | Beagle dog inflammation knee joint tumor necrosis factor interleukin |
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