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Neuropeptide Y enhances the inhibitory effects of clonidine on3H-noradrenaline release in synaptosomes isolated from the medulla oblongata of the male rat
Authors:M. Martire  K. Fuxe  G. Pistritto  P. Preziosi  L. F. Agnati
Affiliation:(1) Department of Pharmacology, Catholic University, Rome, Italy;(2) Present address: Department of Histology, Karolinska Institute, Stockholm, Sweden;(3) Department of Human Physiology, University of Modena, Modena, Italy
Abstract:Summary In studies on superfused synaptosomes from the rat medulla oblongata, the inhibitory effects of theagr2-adrenergic agonist clonidine (0.1mgrM) on potassium (15 mM K+) induced3H-noradrenaline (NA) release was potentiated by 20%, when neuropeptide Y was added to the system. The effect of NPY was detectable at low concentrations (1 nM) and was not dose-dependent. Neuropeptide Y alone produced no significant effects on3H-NA release. The results may indicate the existence of a presynaptic NPY receptor on the noradrenaline and/or adrenaline nerve terminals, which may enhance the presynapticagr2-adrenoreceptor function to inhibit3H-NA release.
Keywords:Neuropeptide Y  presynaptic  /content/g045610001m87636/xxlarge945.gif"   alt="  agr"   align="  BASELINE"   BORDER="  0"  >2-adrenoreceptors  noradrenaline release  superfused synaptosomes  medulla oblongata
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