| 冻融胚胎移植妊娠结局及出生缺陷情况分析 |
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| 引用本文： | 李敏,陈士岭,罗琛,钟梅,倪运萍.冻融胚胎移植妊娠结局及出生缺陷情况分析[J].实用妇产科杂志,2009,25(7). |
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| 作者姓名： | 李敏 陈士岭 罗琛 钟梅 倪运萍 |
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| 作者单位： | 南方医科大学南方医院,广东,广州,510515 |
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| 基金项目： | 国家重点基础研究发展规划(973计划)，国家自然科学基金，广东省自然科学基金 |
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| 摘 要： | 目的:探讨冻融胚胎移植妊娠结局及出生缺陷情况.方法:回顾性研究本中心冻融胚胎移植654周期妊娠结局及出生儿随访观察.结果:654周期中有232例妊娠,临床妊娠187例(28.6%),早期流产31例(16.5%),晚期流产2例(1.1%),异位妊娠8例(4.2%),宫内宫外同时妊娠2例(1.1%).共分娩144例.分娩率23.6%,足月分娩117例(81.1%),早产27例(18.9%),单胎107例(74.3%),单胎早产率9.3%,双胎37例(25.9%),双胎早产率45.9%.获得新生儿180个,男婴89个,女婴91个,其中低体重儿27个(14.9%).新生儿出生缺陷4例,占2.2%,其中1例新生儿死亡.远期随访89例,111个出生儿,年龄1～6岁,新增出生缺陷4例,失访31例(25.8%).总的出生缺陷共8例(4.4%).结论:冻融胚胎移植的早期流产率增加,新生儿畸形发生率与新鲜周期相似,但长期随访出生缺陷率增高,该技术的安全性问题需得到重视,有待进一步随访研究.
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| 关 键 词： | 冷冻胚胎移植 妊娠结局 出生缺陷 |
Perinatal outcome and Birth Defect of Children Born after Frozen/thawed Embryo Transfer |
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| LI Min,CHEN Shiling,LUO Chen,et alCorresponding author:CHEN Shiling.Perinatal outcome and Birth Defect of Children Born after Frozen/thawed Embryo Transfer[J].Journal of Practical Obstetrics and Gynecology,2009,25(7). |
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| Authors: | LI Min CHEN Shiling LUO Chen Corresponding author:CHEN Shiling |
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| Institution: | The Assisted Reproduction Centre of Nanfang Hospital;Nanfang Medical University;Guangzhou Guangdong 510515;China |
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| Abstract: | Objective:To explore the perinatal outcome and the prevalence of birth defect of babies conceived from the use of Frozen-thawed embryo transfer(FET).Methods:A retrospective analysis was used to review the perinatal outcome and to follow up the children conceived from 654 cycles of cryopreserved embryos in our center between 2001 and 2007.Results:In the 654 cycles performed FET,187 clinical pregnancies were achieved.The clinical pregnancy rate was 28.6%,biochemical pregnancy rate was 19.4%,spontaneous aborti... |
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| Keywords: | Frozen embryo transfer Pregnancy outcome Birth detect |
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