Towards a functional organization of episodic memory in the medial temporal lobe |
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Authors: | Eichenbaum Howard Sauvage Magdalena Fortin Norbert Komorowski Robert Lipton Paul |
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Affiliation: | Center for Memory and Brain, Boston University, Boston, MA 02215 USA. hbe@bu.edu |
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Abstract: | Here we describe a model of medial temporal lobe organization in which parallel "what" and "where" processing streams converge within the hippocampus to represent events in the spatio-temporal context in which they occurred; this circuitry also mediates the retrieval of context from event cues and vice versa, which are prototypes of episodic recall. Evidence from studies in animals are reviewed in support of this model, including experiments that distinguish characteristics of episodic recollection from familiarity, neuropsychological and recording studies that have identified a key role for the hippocampus in recollection and in associating events with the context in which they occurred, and distinct roles for parahippocampal region areas in separate "what" and "where" information processing that contributes to recollective and episodic memory. |
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