大豆异黄酮对高脂血症大鼠体内SOD、GSH-Px活力及MDA含量的影响

目的研究大豆异黄酮(SI)对高脂血症大鼠体内SOD、GSH-Px活力及MDA含量的影响。方法50只Wister大鼠随机分为5组,分别接受基础饲料,高脂饲料及高脂饲料分别添加大豆异黄酮30mg/kg,90mg/kg和270mg/kg处理,实验6周。结果与正常对照组比较,高脂血症大鼠脑组织SOD活力,肝脑组织GSH-Px活力都有明显降低(P<0.01),肝脑组织中的MDA含量则升高;而添加SI的高脂血症大鼠体内SOD,GSH-Px活力有不同程度升高(P<0.05～P<0.01),而以低中剂量的SI作用显著(P<0.01),肝脑组织中的MDA含量降低。结论适宜剂量的SI对高脂血症大鼠体内SOD、GSH-Px活力有明显升高作用,而对MDA含量有明显降低作用。

Effect of Soybean Isoflavone on SOD, GSH-Px Activity and MDA Content in Hyperlipemia Rats

Objective To study the effect of soybean isoflavone (SI) on SOD, GSH-Px activity and MDA content of body in hyperlipemia rats. Methods Fifty Wister rats were randomly divided into five groups and fed on foundation feed (normal control, NC), high fat feed (high control, HC), and high fat feed mixed with 30 mg/kg, 90 mg/kg and 270 mg/kg soybean isoflavone respectively. The experiment lasted for 6 weeks. Results Compared with NC group, the activity of SOD and GSH-Px in liver and brain in HC group was significantly decreased, but MDA content was significantly increased ( P <0.01). Compared with high dose group, SI at low and middle dose increased significantly the activity of SOD and GSH-Px in liver and brain ( P <0.01), but decreased MDA content. Conclusions SI at moderate dose can increase the activity of SOD and GSH-Px in liver and brain, and decrease the MDA content significantly.