| 冠状动脉缺血和再灌注后微血管阻塞:诊断和治疗 |
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| 引用本文： | 黄震华. 冠状动脉缺血和再灌注后微血管阻塞:诊断和治疗[J]. 中国新药与临床杂志, 2012, 0(8): 447-450 |
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| 作者姓名： | 黄震华 |
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| 作者单位： | 上海交通大学医学院附属第九人民医院心血管病研究室 |
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| 摘 要： | 冠状动脉阻塞和再灌注后可出现微血管阻塞,导致病情恶化、并发症和死亡率增加。微血管阻塞与心肌肿胀压迫微血管、微血管内皮细胞突向管腔、微栓子脱落、炎症细胞和血小板黏附聚集等有关。冠状动脉造影、心肌红色分级、心肌对比剂超声、磁共振、心电图有助于微血管阻塞的诊断。远端保护器、抗血小板药物、维拉帕米、腺苷等对微血管阻塞可能有治疗作用。
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| 关 键 词： | 心肌梗死 冠状血管造影术 再灌注损伤 微血管性心绞痛 |
Diagnosis and treatment of microvascular obstruction after coronary artery ischemia and reperfusion |
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| HUANG Zhen-hua. Diagnosis and treatment of microvascular obstruction after coronary artery ischemia and reperfusion[J]. Chinese Journal of New Drugs and Clinical Remedies, 2012, 0(8): 447-450 |
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| Authors: | HUANG Zhen-hua |
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| Affiliation: | HUANG Zhen-hua (Cardiovascular Research Room,the Ninth People’s Hospital,Medical College,Shanghai Jiaotong University, SHANGHAI 200011,China) |
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| Abstract: | Coronary artery ischemia and reperfusion may induce microvascular obstruction,resulting in disease progression,complications and increased mortality.The causes of microvascular obstruction may be related to myocytes edema,endothelial cells protrusions,microembolism,inflammation cells and platelet adhesion.Coronary angiography,myocardial blush grading,myocardial contrast echocardiography,magnetic resonance imaging,electrocardiogram may be helpful for the diagnosis of microvascular obstruction.Distal protection device,anti-platelet drugs,velapamil,adenosine may be useful for the treatment of microvascular obstruction. |
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| Keywords: | myocardial infarction coronary angiography reperfusion injury microvascular angina |
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