153Sm-EDTMP致血液学毒性的多因素分析

目的 探讨^153Sm-乙二胺四甲撑膦酸（^153Sm-EDTMP）治疗导致白细胞、血小板降低发生的相关因素。方法 回顾性地整理206例^153Sm-EDTMP治疗后患者的资料，运用Logistic回归对数据进行单因素和多因素分析，对有意义的指标进行分析。结果 单因素分析结果表明：^153Sm-EDTMP治疗后，血液学毒性的发生与患者的年龄、骨转移灶数目、治疗前化疗史、同时进行外放疗、治疗次数有关；多因素分析结果显示，治疗前化疗史、同时进行外放疗、治疗次数等因素与血液学毒性产生与否有关；治疗前靠药物维持正常血象者也易出现血液学毒性。结论 ^153Sm-EDTMP治疗后血液学毒性的发生与几个因素有关，对有这些因素的患者，应特别注意治疗后血象的变化。

Multi-factor analysis on events related to hematological toxicity in 153Sm-EDTMP palliative therapy for skeletal metastases

Objective To investigate the clinical factors related to hematological toxicity induced by intravenous samarium-153 ethylenediaminetetramethylene phosphonic acid( ~(153)Sm-EDTMP) treatment. Methods (A total of) 206 patients with bony metastases treated with ~(153)Sm-EDTMP were retrospectively analyzed.Logistic regression(SPSS 10.0 for Windows) and correlation analysis were used to evaluate the factors concerned. Results Age of the patient,number of bone metastatic lesion,chemotherapy before ~(153)Sm-EDTMP therapy,concurrent radiotherapy and repeat-times of ~(153)Sm-EDTMP treatments were found the individual factors related to hematological toxicity.Chemotherapy before ~(153)Sm-EDTMP,concurrent radiotherapy,medication for normal blood counting and repeat-times of ~(153)Sm-EDTMP treatments were the hematological toxicity factors in multi-factor analysis. Conclusion In ~(153)Sm-EDTMP therapy,several factors were found related to hematological toxicity suggesting more attention be paid to the change of blood cell counting after the palliative therapy.