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| Bufalin的急性毒性研究 | |
| 引用本文： | 齐刚,张莉,何文彤,陈小义,呼文亮. Bufalin的急性毒性研究[J]. 武警医学院学报, 2004, 13(1): 10-11 |
| 作者姓名： | 齐刚 张莉 何文彤 陈小义 呼文亮 |
| 作者单位： | 1. 武警医学院中心实验室,天津,300162 2. 武警医学院药剂教研室,天津,300162 3. 武警医学院组织胚胎学教研室,天津,300162 4. 武警医学院科研部,天津,300162 5. 武警医学院训练部,天津,300162 |
| 摘 要： | 目的：测定Bufalin的近似半数致死量(LD50)并研究Bufalin的急性毒性。方法：采用近似LD50测定方法测定Bufalin的LD50，采用HE染色法检查Bufalin的心肌毒性。结果：本研究表明，Bufalin近似的LD50为2．35mg／kg，并可导致心肌炎细胞浸润、充血等。结论：Bufalin具有一定的心肌毒性。 |
| 关 键 词： | Bufalin 急性毒性 半数致死量 |
| 文章编号： | 1008-5041(2004)01-0010-02 |
| 修稿时间： | 2003-05-24 |
The study on acute-toxicity of Bufalin |
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| QI Gang,ZHANG Li,HE Wen-tong,CHEN Xiao-yi,HU Wen-liang. The study on acute-toxicity of Bufalin[J]. Acta Academiae Medicinae CPAPF, 2004, 13(1): 10-11 | |
| Authors: | QI Gang ZHANG Li HE Wen-tong CHEN Xiao-yi HU Wen-liang |
| Abstract: | Objective: To study the approtimete LD50 of Bufalin and investigate the acute toxicity of Bufalin on the myocardium. Methods: The approximate LD50 assay methods was used and the toxicity of Bufalin on the myocardium was worked-up by HE staining methods. Results: It was showed that the approximate LD50 of Bufalin is 2.35mg/kg, and induced the inflammation soakage and congest of cardiac muscle cell. Conclusion: The toxicity on cardiac muscle of Bufalin was hinted and the approximete LD50 of Bufalin is 2.35 mg/kg. |
| Keywords: | Bufalin Acute toxicity LD50 |
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