鼠伤寒杆菌核糖体制剂用作血吸虫抗原佐剂的探讨

目的：探讨鼠伤寒杆菌核糖体制剂对血吸虫抗原的佐剂作用。方法：小鼠分别用鼠伤寒杆菌核糖体制剂（ＳＴＲＰ）加日本血吸虫成虫抗原（ＳＷＡ）和日本血吸虫成虫抗原免疫后，其体液免疫水平用ＥＬＩＳＡ检测，保护性免疫力用减虫率表示。结果：用ＳＴＲＰ＋ＳＷＡ免疫的小鼠的抗体水平显著高于单用ＳＷＡ免疫的小鼠。尾蚴攻击感染后，ＳＴＲＰ＋ＳＷＡ免疫组小鼠和ＳＷＡ免疫组小组的减虫率，分别为４７％和１７％，前者高于后者。结论：ＳＴＲＰ可以增强小鼠对血吸虫抗原的体液免疫应答反应，并且可诱导小鼠产生较强的抗尾蚴攻击感染能力。

ADJUVANT EFFECT OF SALMONELLA TYPHIMURIUM RIBOSOME ON SCHISTOSOME ANTIGEN

AIM:To explore the adjuvant effect of Salmonella typhimurium ribosome preparation (STRP)on adult schistosome antigen (SWA). METHOD:Mice were immunized with STRP SWA and SWA, respectively.Humoral immunity levels of mice were detected by ELISA and protective immunity of mice were indicated by worm reduction rate. RESULTS:The antibody level of mice immunized with STRP SWA was significantly higher than that of mice immunized with SWA. After cercariae challenge infection,the worm reduction rate of mice immunized with STRP SWA was also significantly higher than that of mice immunized with SWA. CONCLUSION:It is suggested that STRP can enhance the humoral response of mouse to SWA and elicit stronger resistance to schistosome cercariae challenge infection.