血清同型半胱氨酸与冠状动脉病变的相关性研究

目的探讨血清同型半胱氨酸（HCY）水平与急性冠状动脉（下称冠脉）综合征患者冠脉病变支数及冠脉狭窄程度（以Gensini冠脉病变积分为评价标准）的相关性。方法以酶联免疫吸附试验（ELISA）法检测急性冠脉综合征患者（ACS组，n=51）、稳定型心绞痛患者（SA组，n=20）、非冠心病患者（NCHD组，n=23）的血清HCY水平，并分析其与冠心痛严重程度的关系。结果ACS组患者血清HCY水平高于NCHD组和SA组患者，差异均有统计学意义（均P〈0．01）；SA组患者血清HCY水平高于NCHD组，差异有统计学意义（P〈0．05）；ACS组患者外周血清HcY水平与冠脉病变支数呈正相关，差异有统计学意义（r=0．497，P〈0．01），且与Gensini积分呈正相关，差异有统计学意义（r=0．446，P〈O．01）。结论ACS组患者血清HCY水平明显高于SA组和NCHD组患者，表明该指标可能与冠脉易损斑块的病理生理相关；ACS患者血清HCY水平与冠脉病变支数及Gensini积分呈正相关，进一步提示血清HCY水平的升高可能与急性冠脉综合征的发生发展相关。

The study on the relationship between the serum levels of homocysteine and the coronary artery lesions

Objective To investigate the relationship between the peripheral serum level of homoeysteine （HCY） and the severity of coronary artery lesions in patients with acute coronary syndrome. Methods The serum level of HCY was measured by ELISA in 51 patients with acute coronary syndrome （ACS group, n = 51）, 20 with stable angina （SA group, n= 20） and 23 with non-coronary heart disease （NCHD group, n= 23）. The relationship between the peripheral serum level of HCY and the severity of coronary artery lesions was explored. Results The serum level of HCY was significantly increased in ACS group compared with SA group and NCHD group （P〈0.01）; the serum level of HCY in SA group was significantly higher than that in NCHD group （P〈0. 05）. The serum level of HCY in ACS group was correlated positively with the number of coronary artery stenosis （r= 0. 497, P〈0.01 ）, and also correlated positively with Gensini score（r=0. 446,P〈0.01）. Conclusion The serum level of HCY was significantly increased in the patients with ACS, which suggested that they would be associated with coronary plaque vulnerability; the serum level of HCY was correlated positively with the number of coronary artery stenosis and Gensini score,which suggested that they would promote the formation and development of coronary atherosclerosis.