Inhibitory and bactericidal activities of gemifloxacin and other antimicrobials against Mycoplasma pneumoniae |
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Authors: | Waites Ken B Crabb Donna M Duffy Lynn B |
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Institution: | a Department of Pathology, WP 230, University of Alabama at Birmingham, 619n 19th Street South, Birmingham, AL 35249, USA b Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA |
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Abstract: | The MIC of gemifloxacin was compared with that of sparfloxacin, levofloxacin, moxifloxacin, gatifloxacin, ciprofloxacin, doxycycline, erythromycin, azithromycin and clarithromycin using 97 clinical isolates of Mycoplasma pneumoniae. MBCs of fluoroquinolones were determined for a subgroup of 12 isolates. Macrolides were the most potent agents with MIC90s for all drugs 0.001 mg/l. The doxycycline MIC90 was 0.5 mg/l. Gemifloxacin MICs ranged from 0.001 to 0.25 mg/l. The gemifloxacin MIC90 (0.125 mg/l) was equivalent to moxifloxacin and gatifloxacin, was 2-fold lower than sparfloxacin, 8-fold lower than levofloxacin and 32-fold lower than ciprofloxacin. MBCs for gemifloxacin were predominantly within 2–4 times the corresponding MIC values, indicating a bactericidal effect. |
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Keywords: | Mycoplasma pneumoniae MIC MBC Fluoroquinolones Macrolides |
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