| 氢气对百草枯中毒大鼠急性肺损伤的保护作用 |
| |
| 引用本文： | 李孝全,彭兴国,刘克地,胡俊华,付守芝.氢气对百草枯中毒大鼠急性肺损伤的保护作用[J].郧阳医学院学报,2010,29(1):25-27,F0004. |
| |
| 作者姓名： | 李孝全 彭兴国 刘克地 胡俊华 付守芝 |
| |
| 作者单位： | 郧阳医学院附属人民医院急诊科,湖北 十堰,442000 |
| |
| 基金项目： | 十堰市科技局科技计划项目 |
| |
| 摘 要： | 目的:探讨氢气对百草枯中毒大鼠急性肺损伤的保护作用。方法:24只大鼠随机分为3组:对照组、百草枯组和氢气组,百草枯组和氢气组腹腔注射百草枯(35mg/kg),氢气组于注射后立即开始吸入含2%氢气的空气。72h后检测肺湿/干比、肺泡灌洗液PMN、PaO2、肺损伤评分、肺组织丙二醛含量。结果:与对照组比较,百草枯组、氢气组肺湿/干比、肺泡灌洗液PMN、肺损伤评分、肺组织丙二醛含量升高,PaO2降低;与百草枯组比较,氢气组肺湿/干比、肺泡灌洗液PMN、肺损伤评分、肺组织丙二醛含量降低,PaO2升高。结论:吸入氢气能够通过抑制脂质过氧化,抑制白细胞在肺部的聚集,从而减轻百草枯中毒后引起的急性肺损伤。
|
| 关 键 词： | 急性肺损伤 大鼠 百草枯 氢气 |
The Effect of Hydrogen on Paraquat-induced Acute Lung Injury in Rats |
| |
| LI Xiao-quan,PENG Xing-guo,LIU Ke-di,HU Jun-hua,FU Shou-zhi.The Effect of Hydrogen on Paraquat-induced Acute Lung Injury in Rats[J].Journal of Yunyang Medical College,2010,29(1):25-27,F0004. |
| |
| Authors: | LI Xiao-quan PENG Xing-guo LIU Ke-di HU Jun-hua FU Shou-zhi |
| |
| Institution: | LI Xiao-quan,PENG Xing-guo,LIU Ke-di,HU Jun-hua,FU Shou-zhi (Department of Emergency,Renmin Hospital,Yunyang Medical College,Shiyan,Hubei 442000,China) |
| |
| Abstract: | Objective To evaluate the effect of hydrogen on paraquat-induced acute lung injury in rats.Methods Twenty-four SD rats were randomly divided into control group,paraquat group and hydrogen group.The rats in paraquat group and hydrogen group were intraperitoneally injected with paraquat(35 mg/kg).The rats in hydrogen group were given inhalation exposure to air containing 2% hydrogen after injection.The lung wet/dry weight ratio,bronchoalveolar lavage fluid (BALF) PMN,PaO2,lung injury score,and malondialdehyde... |
| |
| Keywords: | Acute lung injury Rat Paraquat Hydrogen |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
