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Effect of β-endorphin on cell growth and cell death in human peripheral blood lymphocytes |
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| Authors: | Riccardo Ientile, Tiziana Ginoprelli, Giuseppe Cannav , Isa Picerno,Giuseppe Piedimonte |
| Affiliation: | a Istituto di Scienze Biochimiche e Biochimica Clinica, Facoltà di Medicina e Chirurgia, Università di Messina, Viale Italia 137, 98100 Messina, Italy b Dipartimento di Igiene Medicina Preventiva e Sanità Pubblica ‘R. De Blasi', Facoltà di Medicina e Chirurgia, Università di Messina, Via T. Cannizzaro 278, 98100 Messina, Italy c Istituto di Patologia Generale ed Anatomia Patologica Veterinaria, Facoltà di Medicina Veterinaria, Università di Messina, Via S. Cecilia 30, 98100 Messina, Italy |
| Abstract: | Beta-endorphin (β-end) was investigated for its ability to influence sequential metabolic events that accompany the movements of T-lymphocytes into the cell cycle. When cultured lymphocytes are exposed to this endogenous opioid peptide an increase in polyamine transport across cell membrane is observed. This membrane modification is an early cell cycle event, whose enhancement leads to the intracellular polyamine accumulation. It is shown that β-end is able to enhance spermidine transport and that the exposition of cells to this peptide is perceived as an apoptotic signal. The possible relationship between induction of apoptotic death and enhancement of polyamine uptake is discussed. |
| Keywords: | β-endorphin Opioid immunomodulation Polyamines Cell cycle Apoptosis Spermidine transport |
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