Survivin与环氧合酶2在子宫颈癌中的表达及二者相关性研究．

目的观察Survivin和环氧合酶2（COX-2）在子宫颈癌组织中的表达及其相关性，探讨其与子宫颈癌发生、发展的关系。方法应用免疫组织化学SABC法检测60例子宫颈癌组织及30例正常子宫颈组织中Survivin和COX-2的表达。结果Survivin和COX-2在子宫颈癌组织中的阳性表达76．7％（46／60），63.3％（38／60）]显著高于在正常子宫颈组织中的阳性表达6．7％（2／30），10．0％（3／30）1（P〈0．05）。Survivin和COX-2的表达与年龄、临床分期、组织分化程度、浸润深度均无相关性（P〉0．05），COX-2表达与淋巴结转移有相关性（P〈0．05），Survivin表达与淋巴结转移之间无相关性（P〉0．05）。在子宫颈癌组织中Survivin表达和COX-2的表达呈正相关（r=0．751，P〈0．05）。结论Survivin和COX-2在子宫颈癌中表达增高；二者在子宫颈癌细胞凋亡抑制过程中可能起协同作用。

Expression of Survivin and cyclooxygenase-2 and their relationship in cervical carcinoma

Objective To investigate the Survivin and Cyclooxygenase-2 （COX-2） expression and their relationship in cervical carcinoma tissues and to investigate the relationship with the genesis and development of cervical carcinoma.＇ Methods The expression of Survivin and COX-2 was assayed by immunohistochemical technique in 60 cervical carcinoma and 30 normal cervical tissue specimens. The relation with its elinieal pathology characters were analysed. Results Survivin and COX-2 expression in the tissues of cervical carcinoma 76.7 % （46/60）, 63.3 % （38/60）] were higher than that in normal cervical tissues evidently 6.7 % （2/30）, 10.0 % （3/30）] （P 〈 0.05）. The COX-2 expression in cervical carcinoma was positively associated with lymph node metastasis （P 〈 0.05）, but no correlation was found between COX-2 expression and age, elinieal stages, grades and invasive depth （P 〉 0.05）. Any correlation between Survivin expression and classical prognostie faetors of cervical eareinoma＇was found. Moreover, these two proteins were positively correlated. Conclusion The Survivin and COX-2 might play important roles in the development of cervical eareinoma.