重组人生长激素对术后患者微量元素代谢的影响

目的观察重组人生长激素(rhGH)对胃肠外科术后患者微量元素锌、铜、铁代谢的影响。方法将42例胃肠外科术后患者随机分成试验组和对照组,收集并分析所有对象的锌、铜、铁摄入量和尿、粪便、引流液排出量。结果肠内、外营养支持下两组对象的锌、铜、铁呈正平衡状态;试验组对象三种元素的正平衡明显高于对照组(P<0.05),尿中锌、铜、铁的排出量呈下降趋势,且低于对照组(P<0.05),粪铜排出量明显低于对照组,铁、锌与对照组相比差异无显著性;试验组对象锌、铜、铁的表观利用率及铜的表观吸收率明显高于对照组(P<0.001);粪中锌、铜、铁排出量,尿中锌排出量与相应元素平衡呈显著负相关。结论消化道术后患者给予重组人生长激素可减少尿中锌、铜、铁的排出,提高机体对锌、铜、铁的利用,有利于机体对锌、铜、铁的储留。

The effect of recombinant human growth hormone on the trace element metabolism in gastroenteric patients after operation

Objective To evaluate the effect of recombinant human growth hormone (rhGH) on the metabolism of Zn, Cu and Fe in gastroenteric patients after operation. Methods 42 gastroenteric patients were randomly divided into rhGH and control groups. Samples of diet,urine, feces and drain were collected, and Zn, Cu, Fe concentrations were measured. Results Positive balances of Zn, Cu, Fe were observed in both groups either with enteral or parenteral nutrition. The balances of rhGH group were higher (P<0.05) than those of control group. In the rhGH group, average urinary contents of Zn, Cu and Fe decreased more rapidly (P<0.05), and the fecal loss of Cu but not Fe and Zn was much lower when compared with the corresponding figures in the control. The apparent utilization of Zn, Cu, and Fe as well as the apparent Cu absorption in the rhGH group were significantly higher (P<0.001) than those of the controls. There were negative correlations between fecal Zn, fecal Cu, fecal Fe, urinary Zn and their balances respectively. Conclusions rhGH administration in gastroenteric patients after operation could reduce urinary Zn, Cu, Fe losses, improve their utilization and was favorable for positive balance and retention.